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| 理肠汤灌胃结合溃疡灵灌肠治疗大鼠溃疡性结肠炎实验研究 | |
| 引用本文： | 黄明河,刘心亮,邵牧民.理肠汤灌胃结合溃疡灵灌肠治疗大鼠溃疡性结肠炎实验研究[J].中国中西医结合消化杂志,2010,18(1). |
| 作者姓名： | 黄明河 刘心亮 邵牧民 |
| 作者单位： | 1. 深圳市中医院,消化内科,广东,深圳,518033 2. 深圳市中医院,中心实验室,广东,深圳,518033 3. 深圳市中医院,病理科,广东,深圳,518033 |
| 基金项目： | 深圳市科技计划项目(200603246) |
| 摘 要： | 目的]观察理肠汤灌胃结合溃疡灵灌肠治疗大鼠实验性溃疡性结肠炎(UC)的疗效。方法]将动物随机分为正常对照(正常)组、模型组、中药治疗小剂量(小剂量)组、中药治疗大剂量(大剂量)组、柳氮磺吡啶(SASP)组。其中除正常组外,其余4组均采用2,4,6-三硝基苯磺酸(TNBS)溶液制作大鼠模型,成功后大、小剂量组分别予大、小剂量理肠汤灌胃及溃疡灵灌肠;SASP组予SASP溶液灌胃,各组灌药时间均为14 d。结果]大剂量组肠黏膜组织学损伤评分显著低于模型组(P0.01);小剂量组、SASP组肠黏膜组织学损伤评分亦低于模型组(P0.05),但小剂量组和SASP组疗效相近(P0.05)。结论]理肠汤灌胃结合溃疡灵灌肠治疗大鼠实验性UC有明显疗效。 |
| 关 键 词： | 结肠炎 溃疡性 中医药治疗 理肠汤 溃疡灵 |
Research on the treatment effect of experimental rats with UC through orally taking Lichang soup and clystering Kuiyang Ling |
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| HUANG Ming-he,LIU Xin-liang,SHAO Mu-min.Research on the treatment effect of experimental rats with UC through orally taking Lichang soup and clystering Kuiyang Ling[J].Chinese Journal of Integrated Traditional and Western Medicine on Digestion,2010,18(1). | |
| Authors: | HUANG Ming-he LIU Xin-liang SHAO Mu-min |
| Institution: | HUANG Ming-he1,LIU Xin-liang2,SHAO Mu-min3(1Digestive Department of Shenzhen Traditional Chinese Medicine Hospital,Shenzhen 518033,China,2Central Lab of Shenzhen Traditional Chinese Medicine Hospital,3Pathology Department of Shenzhen TraditionalChinese Medicine Hospital,Shenzhen 5180033,China) |
| Abstract: | Objective]To observe and study the effects of the treatment on experimental rats with UC through orally taking Lichang Soup and clystering Kuiyang Ling.Methods]Rats were divided randomly by weight into 5 groups:the control group,the model group,group treated with small dose of Chinese medicine,group treated with high dose of Chinese medicine and the SASP therapy group.Except the normal group,the other four groups used 2,4,6-TNBS liquor to make the rat model.After that,different treatments were given to di... |
| Keywords: | colonitisu ulceration Chinese medicine treatment Lichang Soup Kiuyang Ling |
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