子痫前期胎盘组织中TGFβ_1和E-Selectin的表达及意义

目的:探讨子痫前期患者胎盘组织中TGFβ1和E-Selectin的表达。方法:用免疫组化法对20例正常孕妇(对照组)和40例子痫前期患者(子痫前期组,其中轻度16例、重度24例)的胎盘组织进行TGFβ1和E-Selectin定位,并用计算机图像分析系统进行定量比较。结果:①子痫前期组与对照组比较,TGFβ1在胎盘绒毛合体滋养细胞的表达子痫前期组明显高于对照组,而E-Selectin的表达子痫前期组明显低于对照组,两者均有显著性差异(P<0.05),TGFβ1和E-Selectin在轻度、重度子痫前期患者间的表达均无显著性差异(P>0.05);②E-Selectin在胎盘绒毛毛细血管内皮细胞的表达子痫前期组明显高于对照组,差异有显著性(P<0.05),轻度、重度子痫前期患者间无显著性差异(P>0.05)。结论:TGFβ1和E-Selectin可能参与了子痫前期的发病过程。

The research for the expression of TGF β1 and E - Selectin in placenta of patients with pre - eclampsia

Objective:To study the expression of TGF β_1 and E-Selectin in placenta of patients with pre-eclampsia.Methods:20 normal pregnant women(control group) and 40 women with pre-eclampsia(pre-eclampsia group,16 women with mild pre-eclampsia and 24 women with severe pre-eclampsia) were selected.The cellular distribution of TGF β_1 and E-Selectin in placenta in both groups was determined by immunohistochemistry,and the mean density was measured by image analysis system.Results:①The level of TGF β_1 in placental villus syncytiotrophoblast of pre-eclampsia group was significantly higher than that of control group,but the level of E-Selectin in pre-eclampsia group was significantly lower than that of control group,and there were significance in statistics(P<0.05).But there were no significant difference in women with mild pre-eclampsia and severe ones(P>0.05).②The level of E-Selectin in placental villus capillary vascular endothelial cells of pre-eclampsia group was significantly higher than that of control group,and there was significance in statistics(P<0.05),but there was no significant difference in women with mild pre-eclampsia and severe ones(P>0.05).Conclusion:TGF β_1 and E-Selectin may participate in pathogenic process of pre-eclampsia.