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Noma in children with severe combined immunodeficiency
Authors:H A Rotbart  M J Levin  J F Jones  A R Hayward  J Allan  M F McLane  M Essex
Affiliation:1. Department of Orthodontics, University Witten/Herdecke, Witten, Germany;2. Department of Oral and Maxillofacial Surgery, University Hospital of Aachen, Aachen, Germany;3. Department of Orthodontics, University Hospital of Aachen, Aachen, Germany;2. Resident, Department of Maxillo-Facial Surgery and Stomatology, Université Cheikh Anta Diop (UCAD), Hôpital Le Dantec, Dakar, Sénégal;1. Lecturer, Department of Orthodontics and Pediatric Dentistry, School & Hospital of Stomatology, Key Laboratory of Oral Biomedicine of Shandong, Shandong University, Shandong, China;2. Lecturer, Department of Orthodontics, School & Hospital of Stomatology, Laboratory of Oral Biomedicine of Shandong, Shandong University, Shandong, China;3. Professor, Private Practice; Visiting Professor Universidad Internacional de Cataluña, Barcelona, Spain;4. Professor, Department of Orthodontics, School & Hospital of Stomatology, Laboratory of Oral Biomedicine of Shandong, Shandong University, Shandong, China
Abstract:Three Native American children with severe combined immunodeficiency developed noma, a necrotizing gingivostomatitis not previously reported in this country. The similarity between the clinical findings and those observed in monkeys with simian AIDS prompted us to evaluate our patients and their families for human retroviral infection. Antibodies to HTLV-I or HTLV-III/LAV proteins were not identified in patients nor in their family members. Standard bacterial and viral cultures similarly failed to identify a suspect pathogen.
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