| 系统性红斑狼疮患者外周血单核细胞CD40表达及临床意义 |
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| 引用本文： | 黎曼,柴华旗. 系统性红斑狼疮患者外周血单核细胞CD40表达及临床意义[J]. 中国血液流变学杂志, 2010, 20(3): 392-394. DOI: 10.3969/j.issn.1009-881X.2010.03.015 |
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| 作者姓名： | 黎曼 柴华旗 |
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| 作者单位： | 1. 苏州市市立医院北区肾内科,江苏苏州,215008
2. 苏州大学附属第一医院肾内科,江苏苏州,215006 |
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| 摘 要： | 目的 对SLE患者外周血单核细胞上CD40的表达水平及其与SLEDAI评分有无相关性进行分析.方法 用免疫荧光标记和流式细胞仪技术检测21例SLE患者和18名正常人外周血单核细胞上CD40的表达.结果 SLE患者外周血中CD14＋CD40＋/CD14＋百分率明显高于正常对照组（P〈0.01）.SLE患者外周血CD14＋细胞CD40表达水平和SLEDAI评分呈正相关.结论 SLE患者CD14＋CD40＋/CD14＋高于正常人,认为单核细胞CD40表达增高参与SLE的发病过程.
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| 关 键 词： | 系统性红斑狼疮 单核细胞 CD40 |
The Expression of CD40 on Monocytes from SLE Patients and Their Clinical Significance |
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| LI Man,CHAI Hua-qi. The Expression of CD40 on Monocytes from SLE Patients and Their Clinical Significance[J]. Chinese Journal of Hemorheology, 2010, 20(3): 392-394. DOI: 10.3969/j.issn.1009-881X.2010.03.015 |
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| Authors: | LI Man CHAI Hua-qi |
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| Affiliation: | 1 .Department of Nephrology, Suzhou Municipal Hospitat,Suzhou,Jiangsu,215008,China;2.Department of Nephrology, The First Hospital Affiliated to Soochow University, Suzhou,Jiangsu,215006,China) |
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| Abstract: | Objective To analyze whether the expression of CD40 on monocytes of SLE patients is abnormal. Methods The expression of CD40 on monocytes in SLE patients and normal controls was examined by immunofluorescence and flow cytometry. Result The percentage of CDI4＋CD40＋ among CD14＋ cells from patients with SLE is higher than that of normal controls.There is positive relationship between the expression of CD40 on monocytes from SLE patients and SLEDA1 scores.Conclusion The elevated expression of CD40 on monocytes of SLE patients may take part in the pathogenesis of SLE. |
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| Keywords: | CD40 |
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