Gentamicin ototoxicity induced apoptosis of the vestibular hair cells of guinea pigs |
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| Authors: | T Nakagawa H Yamane S Shibata Y Nakai |
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| Institution: | 1. Department of Otorhinolaryngology, Osaka City University Medical School, 545, Osaka, Japan
2. Department of Otorhinolaryngology, Yodogawa Christian Hospital, 2-9-26 Awaji Higashiyodogawa-ku, 533, Osaka, Japan
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| Abstract: | To clarify mechanisms of inner ear cell death induced by aminoglycosides, we used an in situ nick-end labelling method to examine guinea pig vestibular epithelia after chronic systemic treatments with gentamicin to produce apoptosis. Such changes occurred in damaged hair cells, suggesting that this process may be crucial for subsequent repair and cell regeneration. |
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