高血压脑出血患者血清NSE、MMP-9水平变化及其临床价值

目的通过观察急性高血压脑出血患者血清神经元特异性烯醇化酶（NSE）、基质金属蛋白酶-9（MMP-9）水平变化，探讨其临床检测价值。方法选取临床确诊的128例急性高血压脑出血患者及同期体检健康者50例，采用酶联免疫吸附（EusA）法定量检测血清NSE、MMP-9水平，应用SPSS13．0软件包进行统计学处理。结果急性高血压脑出血患者血清NSE、MMP-9水平显著高于健康对照组（P〈0．01），大量出血者血清NSE、MMP-9水平显著高于小量出血者（P〈0．01），意识不清者血清NSE、MMP-9水平显著高于意识清醒者（P〈0．01）。本文死亡率为32．81％（42／128），血清NSE异常组的死亡率（35．7％）显著高于正常组（12．5％）（P〈0．01），血清MMP-9异常组的死亡率（36．1％）显著高于正常组（15．0％）（P〈0．01）。结论怠性高血压脑出血患者血清NSE、MMP-9水平显著升高，血清NSE、MMP-9定量测定可作为判断急性高血压脑出血患者病情轻重及评价发生意外的客观指标。

The changes and clinical value of serum NSE and MMP-9 levels in high blood pressure cerebral hemorrhage patients

Objective Through the observation of acute gastric regurgitation serum NSE and MMP- 9 level change, to investigate the clini- cal testing value. Methods Clinical diagnosis of 128 cases of acute gastric regurgitation the same period and the healthy checkup 50 persons were selected ELISA was used to detect the of serum NSE and MMP - 9 level, SPSS 13.0 package statistics processing. Results In acute gastric regurgitation patieuts, the serum NSE and MMP -9 levels were significantly higher than health in control group（ P 〈 0.01 ）,with a lot hemorrhage serum the NSE and MMP - 9 level was significantly higher than the small hemorrhage （P 〈 0.01 ）, and in unclear persms of serum NSE and MMP- were significantly higher than that in consciousness awake patients（ P 〈 0.01 ）. This mortality was 32.81% （42/128）, the mortality of serum NSE abnormal group （35.7 % ） was significantly higher than normal group （12.5 % ）（ P 〈 0 .01）, serum MMP- 9 abnormal group of mortality rate （36.1% ） was significantly higher than normal group （15.0%）（ P 〈 0.01 ）. Conclusions In acute gastric regurgitation patients, serum NSE and MMP - 9 were significantly increased, serum NSE and MMP - 9 quantitative determination can be used as judge gastric regur- gitation acute illness weight and evaluation accident objective measures.