| 化瘀补肾方提取物干预大鼠子宫内膜异位症 |
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| 引用本文： | 洪敏,华永庆,余黎,孙小玉,李晓冬,朱荃. 化瘀补肾方提取物干预大鼠子宫内膜异位症[J]. 中国中药杂志, 2003, 28(1): 69-72 |
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| 作者姓名： | 洪敏 华永庆 余黎 孙小玉 李晓冬 朱荃 |
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| 作者单位： | 南京中医药大学,规范化中药药理实验室,江苏,南京,210029 |
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| 基金项目： | 国家科技部“十五”攻关项目 ( 2 0 0 1BA70 1A2 9) |
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| 摘 要： | 目的 :研究化瘀补肾方 (TCTS)提取物对内异症模型大鼠的作用。方法 :在手术造成大鼠子宫内膜异位症模型上 ,观察异位内膜组织的重量、病理变化及血清卵巢激素和垂体激素的变化。结果 :TCTS 11.2 g·kg-1,2 2 .5 g·kg-1能明显减小异位内移植物重量 (抑制率分别为 5 0 .9% ,5 3 .7% ) ,内膜移植物腔内面上皮不发达、固有膜变薄、固有膜的基质细胞、腺体样结构减少或消失。同时TCTS能使模型大鼠升高的血清E2 ,FSH ,LH降低。结论 :表明TCTS提取物能够抑制异位内膜组织的生长 ,使其退化、缩小。并且这种作用与血清激素水平的变化有关。
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| 关 键 词： | 化瘀补肾方 子宫内膜异位症 激素 |
| 文章编号： | 1001-5302(2003)01-0069-04 |
| 收稿时间： | 2002-06-26 |
| 修稿时间： | 2002-06-26 |
Effect of TCTS on Experimental Endometriosis of Rats |
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| HONG Min;HUA Yong-qing;YU li;SUN Xiao-yu;LI Xiao-dong;ZHU Quan. Effect of TCTS on Experimental Endometriosis of Rats[J]. China Journal of Chinese Materia Medica, 2003, 28(1): 69-72 |
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| Authors: | HONG Min HUA Yong-qing YU li SUN Xiao-yu LI Xiao-dong ZHU Quan |
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| Affiliation: | National Standard Lab of Pharmacology for Chinese Materia Medica, Nanjing 210029, Jiangsu, China. |
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| Abstract: | Objective:To study the effect of TCTS on endometriosis rats. Method: On the model of surgical induced rat endometriosis, weight and pathological changes of endometrial transplant and serum hormones were observed. Result: Weight of endometrial transplants was reduced by TCTS 11.2 g·kg-1 and 22.5 g·kg-1 and transplants of TCTS treated rat showed poorly developed epithelium, thinner stroma, fewer stromal cells and glands. At the same time elevated serum E2,FSH and LH were reduced by TCTS. Conclusion: TCTS can inhibit the growth of endometrial transplants, which is related with serum hormone,especially E2. |
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| Keywords: | TCTS endometriosis hormone |
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