三维适形放疗联合同步化疗治疗中晚期食管癌的临床研究

目的探讨三维适形放疗技术在中晚期食管癌中的应用价值。方法中晚期食管癌患者80例随机分为适形组(三维适形放疗联合化疗)40例和对照组(常规技术放疗联合化疗)40例。比较2组的近期疗效、远期疗效以及毒副反应发生情况。结果适形组治疗总有效率(90.0%)明显高于对照组(72.5%);适形组1a生存率(82.5%)明显高于对照组(62.5%);2组毒副反应发生情况无差异。结论三维适形放疗联合化疗治疗中晚期食管癌近期疗效及1a生存率较好,毒副反应略增加,但患者基本可耐受。

Three- dimensional conformal radiotherapy combined with chemotherapy for advanced esophageal cancer

Objective To investigate the value of three-dimensional conformal radiotherapy in patients with advanced esophageal cancer.Methods Eighty patients with advanced esophageal cancer were equally randomized into conformal group(three-dimensional conformal radiotherapy combined with chemotherapy) and control group(conventional technology radiotherapy combined with chemotherapy).Short-term effect,long-term efficacy and toxicity were observed in the two groups.Results In the conformal treatment group,response rate(90.0%) and 1a survival rate(82.5%) were significantly higher than those of the control group(72.5%,62.5%).There was no difference of the occurrence of toxicity in two groups.Conclusion Short-term effect and 1a survival rate of the three-dimensional conformal radiotherapy combined with chemotherapy for advanced esophageal cancer are better.Though toxicity slightly increases,patients can tolerate.