异丙酚和七氟醚麻醉对新生鼠空间学习和记忆能力的影响

目的探讨异丙酚和七氟醚麻醉对新生鼠空间学习和记忆能力的影响。方法新生7 d龄SD大鼠,每90min给予30 mg/kg异丙酚或七氟醚吸入麻醉6 h,给予葡萄糖溶液组给予对照,于第7周进行Morris水迷宫实验测试空间学习和记忆能力的影响。结果异丙酚麻醉组2～4 d大鼠的潜伏期,游泳距离均明显长于对照组,表明异丙酚麻醉组有着明显的行为缺陷,而七氟醚吸入麻醉组和对照组相比没有明显的差异。结论异丙酚麻醉会引起新生鼠长久的学习和记忆能力的损伤,而七氟醚则没有此影响。

Effects on spatial learning and memory in newborn rats following propofol and sevoflurane anesthesia

Objective To observe the effects of propofol and Sevoflurane anesthesia on spatial learning and memory in mice.Methods Newborn 7 day SD Rat,For propofol anesthesia doses of 30 mg/kg body weight were given every 90 min.For gas administration rats were placed into an incubation chamber,which was connected to an anesthesia system for 6h,control animals received injections of glucose(50 g/L) solution.At the beginning of behavioral testing,animals were 7 weeks old.Results From trail day 2-4,latencies of rats and distance of rat in propofol anesthesia group were significantly longer than those in control group(P<0.05) whereas sevoflurane based anesthesia showed no significantly differences compare to control group.Conclusion Propofol induced persistant learning and memory damage in newborn rat brains whereas sevoflurane based anesthesia did not.