Mitochondrial quality control in acute ischemic stroke |
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Authors: | Hong An Bing Zhou Xunming Ji |
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Institution: | 1.Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China; 2.Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing, China; 3.Interdisciplinary Innovation Institute of Medicine and Engineering Interdisciplinary, Beihang University, Beijing, China; 4.Department of Neurosurgery, Xuanwu Hospital, Xuanwu Hospital, Capital Medical University, Beijing, China |
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Abstract: | Mitochondria play a central role in the pathophysiological processes of acute ischemic stroke. Disruption of the cerebral blood flow during acute ischemic stroke interrupts oxygen and glucose delivery, leading to the dysfunction of mitochondrial oxidative phosphorylation and cellular bioenergetic stress. Cells can respond to such stress by activating mitochondrial quality control mechanisms, including the mitochondrial unfolded protein response, mitochondrial fission and fusion, mitophagy, mitochondrial biogenesis, and intercellular mitochondrial transfer. Collectively, these adaptive response strategies contribute to retaining the integrity and function of the mitochondrial network, thereby helping to recover the homeostasis of the neurovascular unit. In this review, we focus on mitochondrial quality control mechanisms occurring in acute ischemic stroke. A better understanding of how these regulatory pathways work in maintaining mitochondrial homeostasis will provide a rationale for developing innovative neuroprotectants when these mechanisms fail in acute ischemic stroke. |
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Keywords: | Acute ischemic stroke mitochondrial quality control mitochondrial unfolded protein response mitochondrial dynamics mitophagy mitochondrial biogenesis intercellular mitochondrial transfer |
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