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肝癌细胞转铁蛋自受体的表达及WuT9单抗对肝癌细胞的抑制作用
引用本文:饶益平,李绍白.肝癌细胞转铁蛋自受体的表达及WuT9单抗对肝癌细胞的抑制作用[J].华中科技大学学报(医学版),1991(4).
作者姓名:饶益平  李绍白
作者单位:同济医科大学附属同济医院肝病研究所 (饶益平),同济医科大学附属同济医院肝病研究所(李绍白)
摘    要:应用间接免疫荧光法检测了正常人肝组织、肝癌组织及培养的肝癌细胞转铁蛋白受体表达情况。11例肝癌组织中,10例免疫荧光阳性;原代培养的肝癌细胞荧光阳性率为84.1±11.4%,远高于正常肝细胞的阳性率(5.1±2.6%)。WuT9、WuT9-阿霉素连接物在体外对肝癌细胞的生长有明显的抑制作用,对正常肝细胞的影响较小。

关 键 词:受体  转铁蛋白  肝癌  抗体  单克隆  细胞毒作用

Transferrin Receptor Expression in Cells of Hepatic Carcinoma and Influence of Monoclonal Antibody WuT9 on the Growth of Cancer Cells
Rao Yiping,Li Shaobai Institute of Hepatology,Tongji Hospital,Tongji Medical University,Wuhan.Transferrin Receptor Expression in Cells of Hepatic Carcinoma and Influence of Monoclonal Antibody WuT9 on the Growth of Cancer Cells[J].Journal of Huazhong University of Science and Technology(Health Sciences),1991(4).
Authors:Rao Yiping  Li Shaobai Institute of Hepatology  Tongji Hospital  Tongji Medical University  Wuhan
Abstract:Transferrin receptor expression in human normal and cancer liver tissues and in cultured hepatic cancer cells was studied by indirect immunofluo-rescence technique. It was found that immunofluorescence was positive in 10 patients with hepatic carcinoma (among 11 patients). The positive rate in primary culture hepatic cancer cells was 84.1%, which was much higher than that in normal cells, this suggests that there is elevated transferrin receptor expression in cells of hepatic carcinoma. WuT9, WuT9-Adriamycin conjugate inhibited the growth of hepatic cancer cells in vitro, but both exerted little influence on normal liver cells. From the above it may be suggested that the significant difference in the expression of transferrin receptor and in the influence of WuT9 between normal and cancer liver cells may provide a new experimental clue to immunode-tection and biological guiding therapy for hepatic carcinoma.
Keywords:receptors  transferrin  hepatic carcinoma  antibodies  monoclonal  cytotoxicity
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