| 大鼠肝刺激因子对CCl_4致肝损伤小鼠保护作用的机制研究——Ⅰ.HSS的抗氧化作用 |
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| 引用本文： | 安威,张宝弘,梅懋华. 大鼠肝刺激因子对CCl_4致肝损伤小鼠保护作用的机制研究——Ⅰ.HSS的抗氧化作用[J]. 大连医科大学学报, 1990, 0(2) |
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| 作者姓名： | 安威 张宝弘 梅懋华 |
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| 作者单位： | 大连医学院生理学教研室，大连医学院生理学教研室，大连医学院生理学教研室 |
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| 摘 要： | 本工作观察了大鼠肝刺激因子(HSS)对CCl_4损伤小鼠后,肝组织和血清脂质过氧化物丙二醛(MDA)及自由基清除剂谷胱甘肽(GSH)含量的影响。结果发现,HSS(0.1mg/g 体重,ip)可使CCl_4(10%,5ml/kg)中毒后48 h,肝组织 MDA 值的升高幅度明显降低(6.23±0.98/nmol/mg 蛋白vs.4.17±1.67nmol/mg 蛋白,P<0.005),但血清MDA值的下降幅度不明显。同时肝组织GSH含量明显高于CCl_4损伤组(3236±472μg/g vs.2007±589μg/g,P<0.001)。上述结果提示,HSS具有抗氧化作用,降低CCl_4自由基对肝细胞膜的损伤作用,保护受损肝脏。
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| 关 键 词： | 肝刺激因子 四氯化碳 脂质过氧化 自由基 肝损伤 |
Antioxidation of Rat HSS in Acute Hepatic Injury Induced by Carbon Tetrachloride in Mice |
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| An Wei. Antioxidation of Rat HSS in Acute Hepatic Injury Induced by Carbon Tetrachloride in Mice[J]. Journal of Dalian Medical University, 1990, 0(2) |
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| Authors: | An Wei |
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| Affiliation: | An Wei Department of Physiology,Dalian Medical College |
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| Abstract: | Hepatic stimulator substance(HSS)was examined for its ability toinfluence on liver lipidperoxidation(LPO)characterized by MDA andGSH contents in blood and liver tissue in CCl_4-injured mice.Theresults were as follows:0.1mg/g of HSS at single dose 48h after theadministration of CCl_4(10%,5ml/kg)demonstrated a marked reductionof liver MDA content,the serial MDA was also slightly decreased.However,liver GSH content in HSS-treated mice showed 61% ofrecovery from that of CCl_4-injured mice alone,with transformation ofGSSG reduced.These results indicate that HSS might reduce liver LPOand also strengthen the endogenous antioxidative ability of CCl_4-injuredmice. |
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| Keywords: | hepatic stimulator substance(HSS) carbon tetrachloride(CCl_4) free radicals hepatic injury |
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