红细胞直方图对儿童缺铁性贫血诊断及疗效观察意义

目的: 探讨血液分析仪红细胞直方图对儿童缺铁性贫血(IDA)的诊断价值及其在疗效观察中的意义。方法: 选取IDA患儿22例,配比性别相同、年龄相似健康体检者作为对照组。采集标本,以血液分析仪进行检测,观察红细胞直方图及参数,进行统计分析。结果: IDA患儿血红蛋白(Hb)、红细胞计数(RBC)、红细胞比容(HCT)、红细胞平均体积(MCV)、红细胞平均血红蛋白含量(MCH)、红细胞平均血红蛋白浓度(MCHC)均低于对照组(P<0.01),红细胞体积分布宽度(RDW)高于对照组(P<0.01);治疗后Hb、RBC、HCT、MCV、MCH、MCHC、RDW均高于治疗前(P<0.01)。从红细胞直方图看,IDA患儿直方图<30fl的百分比高于对照组(P<0.005),而峰值及终点数值均低于对照组(P<0.01),治疗后、峰值及终点较治疗前升高(P<0.05和P<0.01)。结论: 观察血液分析仪红细胞直方图及血液学参数,对儿童缺铁性贫血的诊断及疗效观察均有重要意义。

Significance of RBC histogram in diagnosis of iron deficiency anemia in children

Objective:To survey the value of RBC histogram in the diagnosis and response observation of children with iron deficiency anemia(IDA).Methods:The RBC histogram and hematological parameters of twenty two children with IDA were observed,and the results were compared with those of the controls.Results:The hemoglobin(Hb),red blood cell count(RBC),hematocrit(HCT),mean corpuscular volume(MCV),mean corpuscular hemoglobin(MCH) and the mean corpuscular hemoglobin concentration(MCHC) of the IDA group were significantly lower than those of the control(P<0.01).The RDW of the IDA group was significantly higher than that of the control (P<0.01).After therapy,the Hb,RBC,HCT,MCV,MCH,MCHC and RDW of the IDA group increased significantly (P<0.01).The RBC histograms jumping off points of most IDA children were less than 30 fl ,which was significantly higher than those of the control(P<0.005) and the peak value and end-point were significantly lower than the control(P<0.01).After therapy,the peak value and end-point of RBC histograms of the IDA children increased significantly(P<0.05 and P<0.01),but still lower than the control(P<0.01).Conclusions:RBC histogram is of great value in the diagnosis and clinical observation of IDA.