Clinical and pathological analysis on Traditional Chinese Medicine syndromes in children with immunoglobulin A nephropathy |
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Affiliation: | Xue Shi,Traditional Chinese Medicine department,Beijing Children’s Hospital Affiliated to Capital Medical University,Beijing 100045,China Nan Zhou,Ying Shen,Renal department,Beijing Children’s Hospital Affiliated to Capital Medical University,Beijing 100045,China Chunju Zhou,Pathology department,Beijing Children’s Hospital Affiliated to Capital Medical University,Beijing 100045,China |
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Abstract: | OBJECTIVE:To evaluate the common Traditional Chinese Medicine(TCM) syndromes and analyze their relationship to clinical and pathological manifestations in children with IgAnephropathy.METHODS:Forty five children diagnosed as having primary IgA nephropathy by renal biopsy for the first time were enrolled in this trial,and their TCM syndromes were evaluated and the distribution of TCM syndromes was observed.All the sick children were growed? according to clinical manifestations and pathological damages,and the differences in TCM syndromes were compared between the groups.RESULTS:The first 5 TCM symptoms were common cold,hyperhidrosis,red dry throat,dark yellow urine and lassitude.In the acute nephritis group,edema and aching pain in loin and knees were significant(P=0.021 and P=0.000).In the severe pathological damage group,edema was obvious(P= 0.004),and 24 h urinary protein was positively correlated with edema(P=0.015) while negatively with common cold(P=0,007).The score of mesangial cell proliferation was correlated with edema,red dry throat and common cold(P=0.006,0.013 and 0.029 respectively).The score of segmental pathological change was positively correlated with edema(P=0.039).CONCLUSION:Common cold,hyperhidrosis,red dry throat,dark yellow urine,lassitude and other symptoms of qi deficiency of the spleen and lung mainly seen in children with IgA nephropathy may bear a close relationship to clinical manifestations and pathological damages. |
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Keywords: | Glomerulonephritis,Immunoglobulin A Children Urination disorders Qi deficiency of spleen and lung |
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