Endoglin基因在妊娠期高血压疾病胎盘中的表达及意义

目的探讨妊娠期高血压疾病患者胎盘组织中Endoglin基因水平的变化及临床意义。方法选择2010年8月至2011年4月在北京军区总医院住院分娩的妊娠期高血压疾病患者共44例（妊娠期高血压疾病组）,其中妊娠期高血压孕妇15例（妊娠期高血压组）,轻度子痫前期孕妇14例（轻度子痫前期组）,重度子痫前期孕妇15例（重度子痫前期组）;以同期正常晚期妊娠孕妇16例为对照组。采用实时定量RT-PCR检测各组孕妇胎盘组织中Endoglin mRNA表达水平。结果妊娠高血压疾病组患者胎盘组织中Endoglin mRNA相对表达量明显高于对照组,差异有统计学意义（P〈0.05）;轻度子痫前期组、重度子痫前期组患者胎盘组织中Endoglin mRNA相对表达量均明显高于对照组,差异有统计学意义（P均〈0.05）。结论 Endoglin在妊娠期高血压疾病患者尤其是轻度子痫前期及重度子痫前期患者胎盘中高度表达,其表达水平可能与病情的发生发展密切相关。

Expression and significance of Endoglin gene in placenta of hypertensive disorders complicating pregnancy

Objective: To explore changes of Endoglin gene in placenta of hypertensive disorders complicating pregnancy and its clinical significance.Methods: From Aug 2010 to Apr 2011,44 patients with hypertensive disorders complicating pregnancy(HDCP) who delivered in General Hospital of Beijing Military Command were recruited in the study group(HDCP group),including 15 women with gestational hypertension(GH group),14 women with moderate preeclampsia(MPE Group) and 15 women with severe preeclampsia(SPE group).Another 16 healthy pregnant women were taken as control group.Quantitative Real Time RT-PCR was used to investigate the expression of Endoglin mRNA in placenta.Results: the expression of Endoglin mRNA in the placenta of HDCP group were significantly elevated than that in control group(P<0.05).The expression of Endoglin mRNA in GH group,MPE group and SPE group were gradually increased.The expression of Endoglin mRNA in placenta of MPE group and SPE group were both obviously higher than that of control group(P<0.05).Conclusions: The expression of Endoglin is significantly increased in placenta in HDCP,especially MPE and SPE.The rising level may be closely related with the occurrence and development of disease.