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| 薏苡仁注射液对小鼠移植性S180肉瘤血管形成抑制的作用 | |
| 引用本文： | 冯刚,孔庆志,黄冬生,黄涛,卢宏达,费雁,冯觉平. 薏苡仁注射液对小鼠移植性S180肉瘤血管形成抑制的作用[J]. 肿瘤防治研究, 2004, 31(4): 229-230,248 |
| 作者姓名： | 冯刚 孔庆志 黄冬生 黄涛 卢宏达 费雁 冯觉平 |
| 作者单位： | 1. 430033,武汉市普爱医院肿瘤科 2. 湖北中医学院2000级研究生 3. 华中科技大学同济医学院2002级博士生 |
| 基金项目： | 湖北省武汉市卫生局资助项目 |
| 摘 要： | 目的 探讨薏苡仁注射液对肿瘤血管形成抑制作用。方法 通过建立动物肿瘤模型 ,运用薏苡仁实验治疗 ,检测其抑瘤率和肿瘤内血管密度 ,以及瘤体VEGF和bFGF表达的改变。结果 薏苡仁具有明显的抑制S180肉瘤生长作用。实验组的S180瘤体内微血管密度均明显低于对照组 ;免疫组化显示薏苡仁大、中剂量组均可下调S180瘤体内VEGF、bFGF的表达。结论 薏苡仁注射液对肿瘤血管形成均有明显抑制作用 ,降低VEGF、bFGF的表达可能是其抑制肿瘤血管形成的主要机制之一。 |
| 关 键 词： | 薏苡仁 血管内皮生长因子 碱性成纤维细胞生长因子 |
| 文章编号： | 1000-8578(2004)04-0229-02 |
| 收稿时间： | 2003-04-08 |
| 修稿时间： | 2003-07-23 |
Experimental Study on Inhibiting Angiogenesis in Mice S180 Sarcoma by Coix Lacryma-Jobi Injection |
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| FENG Gang ,KONG Qing-zhi ,HUANG Dong-sheng ,HUANG Tao ,LU Hong-da ,FEI Yan ,FENG Jue-ping .Wuhan Pu'ai hospital,Wuhan ,China,.Traditional Chinese Medicine of Hubei College,.Tongji Medical College,Huazhong University of Science and Technologe. Experimental Study on Inhibiting Angiogenesis in Mice S180 Sarcoma by Coix Lacryma-Jobi Injection[J]. Cancer Research on Prevention and Treatment, 2004, 31(4): 229-230,248 | |
| Authors: | FENG Gang KONG Qing-zhi HUANG Dong-sheng HUANG Tao LU Hong-da FEI Yan FENG Jue-ping .Wuhan Pu'ai hospital Wuhan China .Traditional Chinese Medicine of Hubei College .Tongji Medical College Huazhong University of Science Technologe |
| Affiliation: | FENG Gang 1,KONG Qing-zhi 1,HUANG Dong-sheng 2,HUANG Tao 3,LU Hong-da 1,FEI Yan 1,FENG Jue-ping 1 1.Wuhan Pu'ai hospital,Wuhan 430033,China,2.Traditional Chinese Medicine of Hubei College,3.Tongji Medical College,Huazhong University of Science and Technologe |
| Abstract: | Objective To investigate the effect of inhibiting angiogenesis by coix lacryma-jobi.Methods The tumor inhibitory rate and the vascular density were tested in animal tumor model with experimental treatment. The expression of VEGF and bFGF were measured by immunohistochemistry.Results Coix lacryma-jobi has inhibitory effect on S180 sarcoma and the vascular density of S180 sarcoma were lower than the control group. The expression of VEGF and bFGF were down-regulated when the middle and high dose were used.Conclusion Coix lacryma-jobi injection has inhibitory effects on S180 sarcoma and strong inhibitory effects on angiogenesis. Its mechanism may be associated with the down-regulating of VEGF and bFGF expression. |
| Keywords: | Coix lacryma-jobi VEGF bFGF |
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