| 佐米曲坦薄膜衣片溶出度研究 |
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| 引用本文： | 单利,高春生,黄健,崔光华,梅兴国.佐米曲坦薄膜衣片溶出度研究[J].解放军药学学报,2007,23(2):143-145. |
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| 作者姓名： | 单利 高春生 黄健 崔光华 梅兴国 |
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| 作者单位： | 军事医学科学院,毒物药物研究所,北京,100850;军事医学科学院,毒物药物研究所,北京,100850;军事医学科学院,毒物药物研究所,北京,100850;军事医学科学院,毒物药物研究所,北京,100850;军事医学科学院,毒物药物研究所,北京,100850 |
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| 摘 要： | 目的 考察佐米曲坦薄膜衣片的体外溶出行为，制订合理的溶出度测定条件。方法 以100ml人工胃液为溶出介质，转速为50r／min，间隔一定时间取样，采用紫外分光光度法测定药物的溶出量。结果 本品溶出完全，主药于30min内即可完全溶出，且溶出均一。结论 本品达到了很好的体外溶出效果。
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| 关 键 词： | 佐米曲坦片剂 溶出度 |
| 文章编号： | 1008-9926（2007）02-0143-03 |
| 收稿时间： | 2005-09-29 |
| 修稿时间： | 2006-08-28 |
Study of the Dissolution Rate of Zolmitriptan Tablets |
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| SHAN Li,GAO Chun-Sheng,HUANG Jian,CUI Guang-Hua,MEI Xing-Guo.Study of the Dissolution Rate of Zolmitriptan Tablets[J].Pharmaceutical Journal of Chinese People's Liberation Army,2007,23(2):143-145. |
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| Authors: | SHAN Li GAO Chun-Sheng HUANG Jian CUI Guang-Hua MEI Xing-Guo |
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| Institution: | SHAN Li, GAO Chun-Sheng, HUANG Jian, CUI Guang-Hua, MEI Xing-Guo (Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850 China) |
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| Abstract: | Aim To evaluate the behavior of zolmitriptan tablets in vitro and establish a method for determining the dissolution condition. Methods 0. 1 mol·L^-1 HCL（100ml） was used as the dissolution medium, and dissolved contents of the drug were determined by UV method. Results It was found that zolmitriptan tablets were rapidly dissolved. Within thirty minute, zolmitriptan in the tablets dissolved completely and the dissolution was uniform. Conclusion zolmitriptan tablets showed rapidly releasing behavior in vitro. |
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| Keywords: | Zolmitriptan tablets Dissolution |
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