| 曲克芦丁对家兔血脂及动脉粥样斑块形成的影响 |
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| 引用本文： | 高观月,钟德桥,曾明贤. 曲克芦丁对家兔血脂及动脉粥样斑块形成的影响[J]. 中国新药与临床杂志, 1991, 0(4) |
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| 作者姓名： | 高观月 钟德桥 曾明贤 |
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| 作者单位： | 武汉市职工医学院生化教研室，武汉市职工医学院生化教研室，武汉市职工医学院生化教研室 武汉 430016，武汉 430016，武汉 430016 |
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| 摘 要： | 60只家兔经动脉粥样硬化造型后,30只用曲克芦丁100mg(2mL),im,qd×4wk,另外30只家兔用生理盐水2mL,im,qd×4wk作比较,发现曲克芦丁明显降低家兔血浆总胆固醇及载脂蛋白B,明显升高高密度脂蛋白胆固醇的作用,(P<0.01),且对动脉粥样硬化斑块形成具有抑制或消除作用,而生理盐水组则无上述作用。
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| 关 键 词： | 曲克芦丁 兔 致动脉粥样化饮食 高密度脂蛋白胆甾醇脂蛋白类 动脉粥样硬化 |
Effects of troxerutin on blood lipids and atheromatous plaque in rabbits |
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| GAO Guan-Yue,ZHONG De-Qiao,ZENG Ming-Xian. Effects of troxerutin on blood lipids and atheromatous plaque in rabbits[J]. Chinese Journal of New Drugs and Clinical Remedies, 1991, 0(4) |
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| Authors: | GAO Guan-Yue ZHONG De-Qiao ZENG Ming-Xian |
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| Abstract: | Atherosclerosis was produced in 60 rabbits by atherogenic diet. Troxe-rutin was injected im 100 mg (2 mL) to 30 rabbits qd x 4 wk; normal saline was injected im 2 mL to the other 30 rabbits qd x 4 wk as control. The results showed that troxerutin markedly increased the high density lipoproteincholesterol and markedly reduced the cholesterol, Apo-B and the atheromatous plaque on aorta as compared with saline. |
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| Keywords: | troxerutin rabbits atherogenic diet HDL cholesterol lipoproteins atherosclerosis |
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