| 水泥及有关原料对大鼠肺脏致纤维化作用的实验研究 |
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| 引用本文： | 杨美玉,章吉芳,赵秀清,许贵华. 水泥及有关原料对大鼠肺脏致纤维化作用的实验研究[J]. 工业卫生与职业病, 1987, 0(3) |
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| 作者姓名： | 杨美玉 章吉芳 赵秀清 许贵华 |
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| 作者单位： | 沈阳市劳动卫生职业病研究所(杨美玉，章吉芳，赵秀清)，沈阳市劳动卫生职业病研究所(许贵华) |
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| 摘 要： | 本文研究了矿渣水泥及有关原料对大鼠肺脏致纤维化和体外肺巨噬细胞存活率的影响。实验分矿渣水泥、生料、熟料、铁粉、矿渣、石英和空白对照等七组。各组大鼠经气管注入50mg/只,染尘后1、3、6、12月分批剖检,测定全肺湿重、干重、胶原蛋白含量和肺、肺门淋巴结病理检查。结果表明:生料和熟料引起轻度肺间质增厚,有网状纤维增生,矿渣水泥和铁粉引起肺间质内少量胶原纤维增生,矿渣引起较明显肺胶原纤维增生。
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| 关 键 词： | 尘肺 水泥 肺纤维化 |
STUDY OF FIBROGENIC EFFECTS OF SLAG CEMENT AND ITS RAW MATERIALS ON RAT LUNG |
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| Yang Meiyu. STUDY OF FIBROGENIC EFFECTS OF SLAG CEMENT AND ITS RAW MATERIALS ON RAT LUNG[J]. Industrial Health and Occupational Diseases, 1987, 0(3) |
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| Authors: | Yang Meiyu |
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| Affiliation: | Shenyang Institute of Industrial Health and Occupational Diseases |
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| Abstract: | The fibrogenic effects of slag cement and its raw materials on rat lung and their effects on the survival rate of alveolar macrophages in vitro were studied. Seven groups were experimented! slag cement, raw material, ripe material, iron, slag, quartz and the control ones. 50mg each of the above mentioned prepared dust particulates was injected intratracheally into each rat. All rats were killed at an interval of 1, 3, 6 and 12 months. The wet/dry weights of the lung and collagen content of the lung were measured. The histopathological findings of the rat lungs and hilar lymphnodes were observed. The results showed that the raw and ripe materials caused the slight thickening of interstitial and an increase of reticulin fibre while slag cement and iron induced an increase of slight collagen fibre, and in case of slag an increase of more collagen fibre was found. |
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| Keywords: | pneumoconiosis cement pulmonary fibrosis |
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