阿立哌唑对首发精神分裂症认知功能康复的持续影响

目的探讨阿立哌唑对首发精神分裂症认知功能康复的持续影响。方法48例首发精神分裂症患者以阿立哌唑治疗52周，治疗前后进行威斯康星卡片分类测验、持续操作试验、阳性与阴性症状量表评定，并与45例正常人对照。结果治疗组在治疗52周后PANSS量表各项指标分值均较治疗前有明显下降（P均〈0．01）；WCST总测验数、正确反应数、持续错误数、非持续错误数及CPT各项指标（分别为66．09±17．82、24．90±1．22、18．50±6．42、22．27±12．16、28．14±2．91）均较治疗前（分别为85．28±19．57、23．45±3．11、26．77±9．53、34．69±15．35、24．36±3．30）有显著性改善（P均〈0．01）；治疗组于治疗后在上述WCST（正确反应数除外）和CPT指标与对照组（分别为56．96±10．54、14．66±9．10、17．35±11．23、31．04±2．19）比较仍有显著性差异（P〈0．05．0．01）；PANSS总分、阳性症状分量表分、阴性症状分量表分的改善与WCST总测验数、持续错误数、非持续错误数呈正相关（r=0．386～0．482，P均〈0．01），与CPT总分呈负相关（r=-0．377～-0．397，P均〈0．01），一般精神病理分量表分与持续错误数呈正相关（r=0．410，P〈0．01）。结论阿立哌唑对精神分裂症的认知功能障碍有持续改善作用，且认知功能的改善与精神症状的改善存在着明显相关。

Persistent Effects of Aripiprazole on Rehabilitation of Cognitive Function in First-onset Schizophrenia

Objective To explore the persistent effects of aripiprazole on rehabilitation of cognitive function in first-onset schizophrenia.Methods 48 patients with schizophrenia(treatment group) were assessed by Wisconsin Card Sorting test(WCST),Continue performance test(CPT) and Positive and Negative syndrome scale(PANSS) before and after treatment by aripiprazole for 52 weeks.45 health volunteers were assessed by WCST and CPT as control group.Results There were significant differences in scores of PANSS(all P<0.01)...