糖尿病心肌病变的研究进展

糖尿病心肌病变是糖尿病心脏并发症的重要组成部分,主要表现为心室舒张功能受损和心功能不全。研究提示,糖尿病时,心肌细胞能量代谢紊乱,功能改变,凋亡增加,促使心肌纤维化的一些细胞因子和炎症因子异常表达。这些发现揭示,糖尿病从多个方面损害心肌细胞,引起心室重构,这为进一步阐明糖尿病心肌病变发病机制提供了有力证据。

Recent progress on diabetic cardiomyopathy

Diabetic cardiomyopathy is a serious complication of diabetes which is aften accompanied with cardiac dysfunction. Studies show that energy metabolic disorders, abnormal function and increased apoptosis of myocardial cells are associated with diabetes. Some cytokines and inflammation factors which contribute to myocar-dial fibrosis are abnormal expressed in diabetic myocardium. The results above indicate that the physiological disfunction of myocardium and ventricular remodling play critical roles in the pathogenesis of diabetic cardiomyopathy.