乳腺导管原位癌c-erbB-2、PR表达与肿瘤组织学及预后的关系

目的 探讨乳腺导管原位癌ｃ－ｅｒｂＢ－２、孕激素受体（ｐｒｏｇｅｓｔｅｒｏｎｅ ｒｅｉｅｐｔｏｒ，ＰＲ）表达与肿瘤组织学及预后的关系。材料和方法 选取无浸润成分的纯导管原位癌５６例，通过免疫组化测定其ｃ－ｃｒｂＢ－２、ＰＲ表达玢析其阳性表达与肿瘤组织学和预后的关系．结果 ５６例中低分化导管原位癌２８例，中分化１５例、高分化１３例。高分化组ｃ－ｅｒｂＢ－２、ＰＲ的阳性率分别为７．６９％，９２．３１％

The relationship between prognosis, histology and expression of c- erbB- 2, PR of breast ductal carcinoma in situ

Objective: To clarify whether the prognosis of breast ductal carcinoma patient and histology related to expression of c-erbB-2, progesterone receptor(PR) of the tumor. Methods: A total of 56 cases of breast pure ductal carcinoma in situ(DCIS)were histologically and immunohistochemically studied. Results: Among 56 DCIS, 28 were poorly-differelltiated, 15 were intermediately-differentiated and 13 were well-differentiated. The positive expression rates of c-erbB-2 and PR were 7.69% and 92.31% in well-differentiated DCIS; 20% and 46.67% in intermediately-differentiated DCIS; 70.43% and 10.71% in poorly-differentiated DCIS, respectively. The positive rate was significently different between the poorly and well differentiated tumor (P<0.01). There were 24 cases received simple mastectomy and 17 underwent modified radical mastectomy. There were no recurrences among these patients and the 5-year survival rate was 100%. In 15 local excision cases, 5 had recurrence between 6-16 months following operation, in which 3 were poorly-differentiated, 1 intermediatelyand 1 well-differentiated. The expression of c-erhB-2 in the five recurrences were positive in 4 cases and negative in 1 cases. Conclusion:The histologic grade of DCIS correlates with the expression of c-erbB-2 and PR. The prognosis was closely related with histologic grade, surgical method and c-erhB-2, PR expression.