通痹胶囊治疗老年患者冠心病心绞痛

目的:探讨通痹胶囊联合西药治疗老年患者冠心病心绞痛的临床疗效,指导临床应用。方法:180例冠心病心绞痛患者,随机分为对照组和研究组各90例,对照组采用常规西药治疗,研究组在对照组的基础上服用通痹胶囊,每次3粒,每日3次,8周为1个疗程。比较两组患者的临床疗效。结果研究组数据脱落4例,对照组脱落数据3例。研究组总有效率88.4%,显著高于对照组的75.9%。两组患者心绞痛发作频次,持续时间,心绞痛积分,服用硝酸甘油后心绞痛缓解时间,硝酸甘油用量均显著降低,组间比较,研究组显著低于对照组。两组患者ST段(ST segment,ST段)下移导联数,T波(T wave,T波)低平导联数,T波倒置导联数均显著下降,组间比较,研究组显著低于对照组。两组患者超敏C-反应蛋白(high sensitive Creactive protein,hs-CRP),同型半胱氨酸(homocysteine junction,HCY),白介素-6(interleukin-6,IL-6),基质金属蛋白酶-9(matrix metallopeptidase 9,MMP-9),髓过氧化物酶(myeloperoxidase,MPO)均显著降低,组间比较,研究组显著低于对照组。结论:通痹胶囊联合常规西药的中西医结合疗法能够明显改善冠心病心绞痛患者的临床症状,降低心绞痛发病频率及缩短发病时间,改善异常心电图,且具有明显的抗氧化及抗炎作用,具有良好的远期临床效益,推荐在临床得到合理的使用。

Analysis of Tongbi Capsule Therapy Effect in Elderly Patients of Coronary Heart Disease and Angina Pectoris

Objective: To investigate the clinical efficacy of Tongbi capsule combined with western medicine in the treatment of elderly patients with coronary heart disease and angina pectoris and guide the clinical application. Method: One hundred and eighty cases of angina patients were randomly divided into the study group and the control group with 90 cases in each. Control group received conventional western medicine treatment. Study group received Tongbi capsules 3 capsules each time, 3 times daily based on the control group, 8 weeks for 1 course. The clinical efficacies of two groups were compared. Result: There were 4 cases in study group and 3 cases in control group lost. The total efficiency in study group was 88.4%,significantly higher than that in control group (75.9%, P<0.05). Angina attack frequency, duration, angina pectoris integral, angina relief time after sublingual nitroglycerin, dosage of nitroglycerin in both groups decreased significantly while those in study group were significantly lower than that in control group. STsegment depression in lead number, T wave flattening the number of leads, T wave inversion number of leads in both groups decreased significantly while those in study group were significantly lower than that in control group. High sensitive C-reactive protein(Hs-CRP),homocysteine junction(HCY),interleukin-6(IL-6),matrix metallopeptidase 9(MMP-9) and myeloperoxidase(MPO)in both groups decreased significantly while those in study group were significantly lower than that in control group. Conclusion: Tongbi capsule combined with conventional western medicine can significantly improve the clinical symptoms in patients with coronary heart disease and angina pectoris, reducing the pathogenesis of angina pectoris frequencies and shorten the onset time, improving the abnormal ECG, and has obviously antioxidant and anti-inflammatory effects, also with long-term clinical benefit good, we recommend it a reasonably use in clinical.