银杏叶提取物治疗急性脑梗死随机对照试验的Meta分析

目的:用Meta分析(Meta-analysis)的方法对国内已公开发表的有关银杏叶提取物治疗急性脑梗死的临床疗效的研究进行综合定量分析,以期为临床治疗脑梗死的选择方案提供参考依据。方法:收集国内已公开发表的有关银杏叶提取物治疗脑梗死的临床疗效的临床随机对照试验共25项,按Meta分析的要求对检索到的原始研究进行质量评估,采用Stata12.0对符合条件的研究进行Meta分析,评价银杏叶提取物治疗脑梗死的临床疗效。结果:符合纳入标准文献共25篇,总样本量2 292例。与对照组比较,银杏叶提取物治疗急性脑梗死的疗效OR合并值为3.35,95%CI(2.57,4.38),神经功能缺损评分加权均数差(WMD)合并值为-3.12,95%CI(-3.96,-2.28)。结论:银杏叶提取物具有提高治疗急性脑梗死有效率、改善神经功能缺损的作用。

Meta-analysis on Random-control Experiment of Treatment of Acute Cerebral Infarction with Ginkgo Biloba Extract

Objective: Studies that have been published in China on the curative effect of Ginkgo biloba extract on acute cerebral infarction were searched and analyzed by Meta-analysis, in order to provide some evidences in treating cerebral infarction. Method: All the studies that have been searched and strictly evaluated through meta-analysis by the software Stata12.0, to evaluate the curative effect of Ginkgo biloba extract on acute cerebral infarction. Result: Totally 25 studies including 2 292 cases were analyzed. Compared with the control group, the OR merge value of neurological Ginkgo biloba extract defect efficacy of treatment of acute cerebral infarction was 3.35,95% CI (2.57,4.38), the OR merger value of neurological deficits therapy weighted mean difference (WMD) was -3.12,95%CI (-3.96,-2.28). Conclusion: Ginkgo biloba extract has the effect to improve the treatment of acute cerebral infarction and improve nerve function defect.