大桑菊合剂治疗小儿肺炎支原体肺炎

目的:探讨大桑菊合剂联合阿奇霉素治疗小儿肺炎支原体肺炎(MPP)的疗效及其双向调控炎症反应的作用。方法:将100例MPP患儿随机按数字表法分为对照组和治疗组各50例。对照组予口服阿奇霉素干混悬剂,按体重10 mg·kg-1,第2~5天,每日按体重5 mg·kg-1,使用5 d后停2 d为1个疗程;治疗组在对照组治疗的基础上,予口服大桑菊合剂,3岁以上,每次10 m L,3次/d;3岁以内,每次5 m L,3次/d,7 d为1个疗程。两组均治疗并观察3个疗程。进行治疗前后患儿的症状及体征记录,并对其进行疗效评价;检验治疗前后(第1天和第21天)肺炎支原体抗体(MP-Ig M),白细胞介素-6(IL-6),白细胞介素-10(IL-10)的血清浓度水平。结果:治疗组体温恢复正常、咳嗽消失、肺部啰音消失均明显比对照组所需时间缩短(P0.05)。治疗组患儿总有效率为88.00%,显著优于对照组(70.00%,P0.05)。治疗组有8例出现胃肠不良反应,对照组则有18例,差异有统计学意义(P0.05)。治疗组IL-6及IL-10血清浓度治疗后与治疗前后差值较对照组均显著降低,差异有明显统计学意义(P0.05)。结论:大桑菊合剂联合阿奇霉素能明显改善MPP患儿临床症状及体征,缩短病程,疗效显著;再者,其能同时显著降低IL-6,IL-10血清浓度,作用机制可能与双向调控炎症反应有关。

Curative on Mycoplasma Pneumoniae of Dasangju Mixture in Children

Objective: The aim of this article was to observe the curative effect of the Dasangju mixture combined with azithromycin on mycoplasma pneumoniae (MPP) in children and investigate the bi-directional control mechanism of inflammatory response. Method: One hundred patients with MPP were randomly divided into control group and observation group with 50 patients in each group by random number table. Patients in control group took 10 mg·kg^-1 azithromycin suspension on the first day as well as 5 mg·kg^-1 orally daily for 4 days and stopped for 2 days, which was a course of treatment. Based on the control group, patients in observation group was added 10 mL Dasangju mixture at a time and three times a day in the children aged above 3 years old, while 5 mL at a time and three times a day in those aged younger than 3 years old. Both groups were treated for 21 days, with 7 days as a course of treatment. Then, the symptoms and signs before and after treatment were recorded and the results were evaluated by efficacy evaluation in Chinese medicine. Moreover, the serum concentrations of myeoplasma pneumoniae-immune gloulin M(MP-IgM), interleukin-6(IL-6), and IL-10 were determined before and after medication on the 1^st day and the 21^st day. Result: The duration of observation group on fever, cough and lung rale were obviously improved than the control group(P<0.05). The total effective rate in observation group was 88.00% while in the control group it was 70.00%, and there was statistical significance(P<0.05). After treatments, both the serum concentrations and the differences between before and after treatment of interleukin-6 and interleukin-10 in observation group were more significantly reduced than in the control group(P<0.05). Conclusion: Dasangju mixture combined with azithromycin can not only improve the clinical symptoms and signs, but also shorten the duration with significant effect. Meanwhile, Dasangju mixture can significantly reduce the concentrations of IL-6 and IL-10, which may be related to bi-directional control mechanism of inflammatory response.