参柏洗剂的制备工艺

目的:优选参柏洗剂的制备工艺,为该制剂的工业化生产提供参考。方法:采用水蒸气蒸馏法提取松叶、荆芥中挥发油,通过单因素试验优选提取工艺。以总生物碱质量浓度和固形物总量的综合评分为指标,通过正交试验考察加水量、提取时间、提取次数对参柏洗剂水提工艺的影响,并通过单因素试验筛选浓缩工艺及成型工艺。结果:最佳制备工艺条件为加14倍量水提取5 h,收集含挥发油蒸馏液,加0.1%聚山梨酯80增溶;药渣与其余4味药材加8倍量水煎煮3次,每次1 h,常压或减压浓缩,加入0.3%苯甲酸钠防腐,冷藏48 h除杂。总生物碱质量浓度不低于195 mg·L-1,保留率不低于85%。结论:该工艺稳定可行,可为参柏洗剂的规范化生产提供实验依据。

Preparation Technology of Shenbo Lotion

Objective: To provide theoretical and experimental basis for industrial production of Shenbo lotion by optimizing its preparation technology. Method: Volatile oil from pine needle and Schizonepetae Herba was extracted by steam distillation method,extraction technology of volatile oil was optimized through single-factor test.With comprehensive score of total alkaloids concentration and solid content as index,orthogonal design was optimized water extraction process by taking water consumption,extracting times and time as factors,concentrating and molding processes were screened by single factor test. Result: Optimum preparation process was as following:extracted 5 h with 14 times the amount of water,added 0.1% polysorbate 80 to solubilizing oil.The rest medical materials with herb residue were boiled thrice with 8 times the amount of water,1 hour for each time.Filtrate was concentrated by atmospheric pressure or reduced pressure,then adding 0.3% sodium benzoate as preservative and purifying after refrigerating 48 hours.The concentration of total alkaloids was no less than 195 mg·L^-1,and its retention rate was no less than 85%. Conclusion: This preparation technology is stable and feasible,it serves as a theoretical basis for standardized production of Shenbo lotion.