全肺灌洗术治疗尘肺的临床效果观察

目的探讨全肺灌洗术治疗尘肺病的临床效果。方法对10例不同期别的尘肺病患者,在静脉复合麻醉下进行双腔支气管插管,并将双肺成功隔离,一侧肺纯氧通气,一侧肺采用灌洗液反复灌洗,并于灌洗前及灌洗后分别测定血气、肺功能。全肺灌洗治疗后动脉血氧分压与治疗前对比其改变有统计学意义(P<0.05);相反,动脉血二氧化碳分压、肺通气功能以及肺弥散功能灌洗治疗前后均无统计学意义(P>0.05)。结果成功进行双肺同期肺灌洗10例,术中顺利,术后临床症状消失,无明显术后并发症。结论全肺灌洗术疗效好、安全,并发症发生少,是治疗尘肺病安全、有效的治疗方法之一。

Cinical Observation on Therapy of Pneumoconiosis with Whole Lung Lavage

Objective To explore the clinical outcomes of whole lung lavage for the therapy of pneumoconiosis. Methods Ten patients with pneumoconiosis at various stage were performed double-lumen endotracheal intubation under the condition of combined intravenous anesthesia, and the bilateral lungs were successfully isolated from each other. Ventilation with oxygen (Fi=1.0) was carried out to one lateral lung and repeated lavage was meanwhile conducted to the other lateral lung. In the end, both the bilateral lungs were given lavage. Blood gas and lung function were detected before and after lavage. The change in arterial partial pressure of oxygen (PaO2) after lavage was statistically significant when it was compared with that before whole lung lavage (P<0.05). On the contrary, there were no obvious differences in arterial partial pressure of carbon dioxide (PaCO2) and lung ventilatory or diffuse fuction between before and after lavage (P>0.05). Results Successful bilateral lung lavage was conducted in the ten patients without obvious postoperative complications. Conclusion Whole lung lavage is effective on pneumoconiosis with safety or few complications.