| 葛根素对局灶性脑缺血-再灌注大鼠的抗氧化作用 |
| |
| 引用本文： | 李佳.葛根素对局灶性脑缺血-再灌注大鼠的抗氧化作用[J].咸宁医学院学报,2007,21(5):373-375. |
| |
| 作者姓名： | 李佳 |
| |
| 作者单位： | 咸宁学院医学院医学基础课实验教学示范中心 湖北咸宁437100 |
| |
| 摘 要： | 目的探讨葛根素对大鼠局灶性脑缺血-再灌注后脑组织中SOD、MDA含量的影响。方法雄性SD大鼠24只,随机分为假手术组、缺血组、葛根素给药组(30 mg/kg),每组8只。采用尼龙线大鼠大脑中动脉栓塞法制造大鼠脑缺血再灌注模型。采用黄嘌呤氧化酶法和硫代巴比妥酸法测定脑组织MDA含量和SOD活性。结果葛根素能明显降低脑组织MDA含量,增加脑组织SOD活性(P<0.01)。结论葛根素通过清除氧自由基而发挥对脑缺血-再灌注后脑组织的保护作用。
|
| 关 键 词： | 葛根素 脑缺血-再灌注 氧自由基 |
| 文章编号： | 1008-0635（2007）05-0373-03 |
| 修稿时间： | 2007-08-20 |
Anti-oxidant Effects of Puerarin on Cerebral Ischemia-Reperfusion in Rats |
| |
| LI Jia.Anti-oxidant Effects of Puerarin on Cerebral Ischemia-Reperfusion in Rats[J].Journal of Xianning Medical College,2007,21(5):373-375. |
| |
| Authors: | LI Jia |
| |
| Institution: | Demonstration Centre of Experimeut-teaching for Foundational Medicine, Xianning College, Xianning Hubei 437100, China |
| |
| Abstract: | Objective To study the effects of puerarin on the level of SOD and MDA following focal cerebral ischemia-reperfusion in rats.Methods 24 male Sprague-Dawley rats were randomly divided into three equal groups: sham group,ischemia group and puerarin dose group.The animal models of middle cerebral artery occlusion(MCAO) were established in rats.At 24h after MCAO(in which the ischemia endures for 2h),the activity of SOD and the content of MDA were measured respectively by xanthine oxidase method and thiobarbituric acid(TBA) method.Results Compared with ischemia group,puerarin could significantly increase the activity of SOD and decrease the content of MDA in brain tissue(P<0.01).Conclusion Puerarin has protective effects on cerebral ischemic injury by enhancing the ability of free radicals scavenging |
| |
| Keywords: | Puerarin Cerebral ischemia-reperfusion Qxygen free redical |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
