| 脂肪酸羟基脂肪酸脂的研究进展 |
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| 引用本文： | 许小芬,胡长锋,朱嫒嫒,张纪达.脂肪酸羟基脂肪酸脂的研究进展[J].中国现代医学杂志,2022(2):43-48. |
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| 作者姓名： | 许小芬 胡长锋 朱嫒嫒 张纪达 |
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| 作者单位： | 1.浙江中医药大学 基础医学院， 浙江 杭州 310053;2.杭州市职业病防治院， 浙江 杭州 310014 |
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| 基金项目： | 国家自然科学基金（No：81774255）；国家重点研发计划（No：2018YFC1705501） |
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| 摘 要： | 脂肪酸羟基脂肪酸脂(FAHFAs)是近年来发现的一类具有抗糖尿病和抗慢性炎症等生物功能的新型内源性脂质.该文详细介绍了FAHFAs的化学结构组成、在生物体内各组织中的分布,以及抗糖尿病、抗炎等生物学功能和检测方法 .另外,由于该类脂质具有抗慢性炎症等功能,因此其可能在风湿免疫性疾病的发病过程中也具有重要作用.
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| 关 键 词： | 脂肪酸羟基脂肪酸脂 糖尿病 自身免疫疾病 |
| 收稿时间： | 2021/8/30 0:00:00 |
The research progress in fatty acid esters of hydroxy fatty acids |
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| Xiao-fen Xu,Chang-feng Hu,Ai-ai Zhu,Ji-da Zhang.The research progress in fatty acid esters of hydroxy fatty acids[J].China Journal of Modern Medicine,2022(2):43-48. |
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| Authors: | Xiao-fen Xu Chang-feng Hu Ai-ai Zhu Ji-da Zhang |
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| Institution: | 1.College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China;2.Hangzhou Hospital for the Prevention and Treatment of Occupational Diseases, Hangzhou, Zhejiang 310014, China |
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| Abstract: | Fatty acid esters of hydroxy fatty acids (FAHFAs) are a new group of endogenous lipids with anti-diabetic and anti-inflammatory effects found in recent years. In this review, the chemical structure of FAHFAs, the distribution of FAHFAs in various tissues, and the mechanisms underlying the anti-diabetic and anti-inflammatory effects of FAHFAs are introduced in detail. In addition, based on the biological functions such as the anti-inflammatory effect, FAHFAs may also play an essential role in the pathogenesis of autoimmune diseases. |
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| Keywords: | fatty acid esters of hydroxyl fatty acids diabetes mellitus autoimmune diseases |
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