帕金森病与炎症相关的研究进展

帕金森病是一种进展性的中枢神经系统变性疾病,主要病理特征是黑质多巴胺能神经元变性死亡和脑干神经元内α突触核蛋白积聚形成路易体。其病因主要为遗传因素和环境因素。该病主要会引起静止性震颤、运动迟缓、肌肉僵直等一系列的运动症状。然而其发病机制并不明确,主要可能与线粒体功能障碍、氧化应激、蛋白质改变及炎症反应相关。小胶质细胞与炎症反应密切相关,而小胶质细胞过度激活是帕金森病发病的病理生理基础。血清炎症因子升高与帕金森病有关,可用于早期诊断并预测疾病预后。目前抗炎治疗成为帕金森病新的研究热点。该文主要综述帕金森病的炎症机制、相关的炎症因子及抗炎药物的研究进展。

Research progress of Parkinson's disease and inflammation

Parkinson''s disease (PD) is a clinically common degenerative disease of the central nervous system. The main pathological mechanism is the degeneration of dopaminergic neurons in the substantia nigra of the midbrain and the loss of dopamine transmitters in the striatum. The causes are mainly genetic factors and environmental factors, The disease mainly causes a series of motor symptoms such as resting tremor, bradykinesia, and muscle rigidity. However, the pathogenesis of PD is not clear, The research found that it may be related to mitochondrial dysfunction, oxidative stress, protein changes and inflammation. Current research has found that microglia are closely related to inflammation response, And in the pathological process of PD, excessive activation of microglia (MG) is the pathophysiological basis of PD pathogenesis. Studies have reported that elevated serum inflammatory factors are related to PD, which can be used to diagnose PD early and predict disease prognosis. At present, anti-inflammatory treatment has become a new research hotspot in PD. More and more studies have found that anti-inflammatory drugs can prevent and treat Parkinson''s disease. This article mainly introduces the inflammatory mechanism of PD, related inflammatory factors and the progress of anti-inflammatory drugs.