Urine metabolic profiling for the pathogenesis research of erosive oral lichen planus |
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| Affiliation: | 1. Department of Pharmacy, GuiYang College of Traditional Chinese Medicine, Guiyang 550025, PR China;2. First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China;3. Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China;1. School of Mechanical and Electrical Engineering, China University of Mining and Technology, Xuzhou 221116, P. R. China;2. School of Materials Science and Engineering, China University of Mining and Technology, Xuzhou 221116, P. R. China;1. Welcome Trust Centre for Human Genetics, Oxford, UK;2. CRUK/MRC Oxford Institute for Radiation Oncology, Oxford, UK;1. Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil;2. Department of Dentistry, Federal University of Sergipe, UFS, Aracaju, SE, Brazil;3. Department of Oral Diagnosis and Therapeutics, Faculty of Dentistry, Federal University of Bahia, UFBA, Salvador, BA, Brazil |
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| Abstract: | ObjectiveOral lichen planus (OLP) is a relatively common chronic immune-pathological and inflammatory disease and potentially oral precancerous lesion. Erosive OLP patients show the higher rate of malignant transformation than patients with non-erosive OLP. Identifying the potential biomarkers related to erosive OLP may help to understand the pathogenesis of the diseases.MethodsMetabolic profiles were compared in control and patient subjects with erosive OLP by using ultra-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF-MS) coupled with pattern recognition methods An integrative analysis was used to identify the perturbed metabolic pathways and pathological processes that may be associated with the disease.ResultsIn total, 12 modulated metabolites were identified and considered as the potential biomarkers of erosive OLP. Multiple metabolic pathways and pathological processes were involved in erosive OLP.ConclusionThe dysregulations of these metabolites could be used to explain the pathogenesis of the disease, which could also be the potential therapeutic targets for the disease. |
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| Keywords: | Erosive oral lichen planus Metabonomics Potential biomarkers |
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