Effect of fluoride toothpaste with nano-sized trimetaphosphate on enamel demineralization: An in vitro study |
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| Institution: | 1. São Paulo State University (Unesp), School of Dentistry, Araçatuba, Department of Pediatric Dentistry and Public Health, Rua José Bonifácio 1193, 16015-050, Araçatuba, SP, Brazil;2. LIEC-Department of Chemistry, Federal University of São Carlos (UFSCar), 13565-905, São Carlos, SP, Brazil;1. Clinic of Operative and Pediatric Dentistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, D-01307 Dresden, Germany;2. Department of Operative Dentistry and Periodontology, Center for Dental Medicine, Medical Center, University of Freiburg, D-79106 Freiburg, Germany;3. Clinic of Operative Dentistry, Periodontology and Preventive Dentistry, University Hospital, Saarland University, Building 73, D-66421 Homburg/Saar, Germany;1. Department of Operative Dentistry, Faculty of Oral and Dental Medicine, Misr International University, Egypt;2. Department of Pediatric Dentistry and Dental Public Health, Faculty of Oral and Dental Medicine, Misr International University, Egypt;1. Department of Biomaterials Science, Faculty of Dentistry, University of Sydney, New South Wales, Australia;2. Institute of Dental Research, Westmead Millennium Institute and Westmead Centre for Oral Health, New South Wales, Australia;3. Restorative Department, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand;1. Department of Preventive and Community Dentistry, Oral Health Research Institute, Indiana University School of Dentistry, 415 Lansing St, Indianapolis, IN 46202, USA;2. GlaxoSmithKline, St. George''s Avenue, Weybridge KT13 0DE, United Kingdom |
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| Abstract: | ObjectiveThis study evaluated the effect of toothpastes containing 1100 ppm F associated or not with micrometric or nano-sized sodium trimetaphosphate (TMP) on enamel demineralization in vitro, using a pH cycling model.DesignBovine enamel blocks (4 mm × 4 mm, n = 96) were randomly allocated into eight groups (n = 12), according to the test toothpastes: Placebo (without fluoride or TMP); 1100 ppm F (1100F); 1100F plus micrometric TMP at concentrations of 1%, 3% or 6%; and 1100F plus nanosized TMP at 1%, 3% or 6%. Blocks were treated 2×/day with slurries of toothpastes and submitted to a pH cycling regimen for five days. Next, final surface hardness (SHf), integrated hardness loss (IHL), differential profile of integrated hardness loss (ΔIHL) and enamel fluoride (F) concentrations were determined. Data were analyzed by ANOVA and Student-Newman-Keuls’ test (p < 0.05).ResultsThe use of 1100F/3%TMPnano led to SHf 30% higher (p < 0.001) and IHL ∼ 80% lower (p < 0.001) when compared to 1100F. This toothpaste also resulted in ∼64% reduction of mineral loss (ΔIHL) when compared to 1100F. Moreover, the addition of nano-sized TMP promoted increases in enamel F uptake of 90%, 160% and 100%, respectively for the concentrations of 1%, 3% and 6%, when compared to 1100F (p < 0.001).ConclusionThe addition of nano-sized TMP at 3% to a conventional toothpaste significantly decreased enamel demineralization when compared to its counterparts without TMP or supplemented with micrometric TMP. |
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| Keywords: | Demineralization Phosphates Toothpastes Nano-sized |
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