幽门螺旋杆菌根治治疗与缺铁性贫血的相关性研究

目的：研究幽门螺旋杆菌（HP）感染与缺铁性贫血（IDA）的相关性，探讨HP根治对IDA治疗效果的影响。方法：选择健康体检志愿者584名，对其进行IDA及HP感染构成情况分析，将其中确诊的61例IDA合并HP感染患者随机分为观察组（31例）和对照组（30例），观察组给予铁剂联合抗HP治疗，对照组单纯给予铁剂治疗，比较两组患者治疗效果。结果：584名志愿者中IDA合并HP感染患者61例；IDA患者HP感染率为55．96％，明显高于非IDA人群的20．21％；HP感染者IDA患病率为38．85％，明显高于HP阴性者的11．24％；HP感染与IDA发病具有显著的相关性（X2=15．3403，P〈0．001）。观察组抗HP治疗药物停用4周后，HP根治29例，根治率93．55％。两组患者治疗后IDA指标均有不同程度改善，其中观察组治疗后1个月、3个月均较治疗前显著上升（t=3．974，t=4．802，t=5．221；P〈0．01）；对照组治疗后1个月仅1项指标较治疗前显著上升（，=5．383，P〈0．01），治疗后3个月虽然各项指标较治疗前显著上升（t=4．446，t=3．741，t=8．221；P〈0．01），但显著低于同期观察组（t=4．201，t=6．664，t=3．847；P〈0．01）。结论：HP感染与IDA密切相关，根治HP感染对改善IDA治疗效果具有重要意义。

Research on H. pyiori eradication treatment with iron deficiency anemia

Objective： To study Helicobacter pylori （HP） infection and iron deficiency anemia （IDA）, to explore the HP radical IDA treatment effect. Methods： To select Hospital 584 healthy volunteers, analysis of the composition of IDA and HP infection, diagnosed 61 cases of IDA merger of HP infection were randomly divided into observation group and control group, observed 51 patients given iron joint anti-HP treatment, the control group of 50 patients treated with iron therapy, the therapeutic effect of the two groups were compared. Results： The group of 584 volunteers, IDA combined HP infection in 61 patients; the IDA patients HP infection rate was 55.96%, significantly higher than the non-IDA crowd the 20.21%; HP infection by IDA prevalence rate of 58.85%, significantly higher than the HPnegative 11.24%; incidence of HP infection and IDA have significant correlation, x2=15.5403, P〈0.001. Four weeks after the observation group anti-HP therapy disable HP cure in 29 cases, the cure rate of 95.55%. After treatment IDA indicators have improved to some extent, the observation group after treatment, 1 month, 3 months increased significantly compared with those before treatment （t=3.974, 4.802, 5.221, 6.308; P〈0.01）; only one indicator of a treatment in the control group after treatment before a significant increase （t=5.383, P〈0.01）, 3 months after treatment, a significant increase in the indicators than before treatment （t=4.446, 3.741, 8.221; P〈0.01）, but significantly lower than the same period in the observation group （t=4.201, 6.664, 3.847; P〈0.01）. Conclusion： HP infection and IDA is closely related to the cure HP infection is of great significance to improve the IDA treatment of effect.