不同复方烫伤制剂的制备及其对兔深Ⅱ°烫伤的修复作用研究

目的:制备不同复方烫伤制剂并研究其对家兔皮肤深Ⅱ°烫伤后的修复作用。方法:将脱毛后的家兔以红外线照射方法复制成深Ⅱ°烫伤模型,以相同药物相同剂量不同剂型的复方烫伤凝胶剂、复方烫伤软膏剂、复方烫伤膜剂为实验组,以湿润烫伤膏为阳性对照组,以生理盐水为空白对照组,处理烫伤模型家兔一定时间后,观察烫伤皮肤创面收缩情况,计算创面收缩直径平均值。结果:3个实验组与湿润烫伤膏阳性对照组烫伤面均无感染,愈合面光滑平整,但3个实验组与湿润烫伤膏阳性对照组愈合时间不同,其中以凝胶剂愈合效果最好,烫伤面无感染,愈合面光滑平整,创面收缩直径较其它组显著减小(P<0.05)。结论:复方烫伤凝胶剂对模型家兔皮肤深Ⅱ°烫伤的修复作用效果显著。

Preparation and Curative Effeets of Different Compound Scald Preparations for Deep Ⅱ° Scald

OBJECTIVE:To prepare different compound scald preparations and to investigate their repairing effects for deep Ⅱ° scald in rabbits.METHODS:The deep Ⅱ° scald model was established in depilated rabbits by infrared radiation.Then the rabbits in the trial groups were treated with the same drug at different dosage and different forms of medication:compound scalded gels,compound scalded ointments and the compound scalded films,with Moist Exposed Burn Ointment as positive control and 0.9% NaCl aqueous solutions blank.After a certain time of treatment,the contraction of the scald skin was observed and the average value of the diameter of the scald skin was calculated.RESULTS:In three trial groups and Moist Exposed Burn Ointment positive control group,no scald infection occurred,and the healing surfaces of the scalds were all smooth and even.However,the healing time was different between 3 trial groups and Moist Exposed Burn Ointment positive control group,with compound scalded gels showing the best efficacy in that the scald surfaces were free from infection,the healing surfaces were smooth and even,and the contracted diameter of the scalded skin was significantly lower than in other groups,showing significant differences as compared with other groups(P<0.05).CONCLUSION:The compound scalded gels have remarkable repairing effect on deep Ⅱ° scald model in skin of the rabbits.