| 信息熵理论在热毒宁口服制剂中金银花与栀子提取工艺优选中的应用 |
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| 引用本文： | 王仁杰,李淼,闫明,杨素德,王振中,萧伟.信息熵理论在热毒宁口服制剂中金银花与栀子提取工艺优选中的应用[J].中草药,2015,46(5):683-687. |
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| 作者姓名： | 王仁杰 李淼 闫明 杨素德 王振中 萧伟 |
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| 作者单位： | 江苏康缘药业股份有限公司, 江苏 连云港 222001;中药制药过程新技术国家重点实验室, 江苏 连云港 222001;江苏康缘药业股份有限公司, 江苏 连云港 222001;中药制药过程新技术国家重点实验室, 江苏 连云港 222001;江苏康缘药业股份有限公司, 江苏 连云港 222001;中药制药过程新技术国家重点实验室, 江苏 连云港 222001;江苏康缘药业股份有限公司, 江苏 连云港 222001;中药制药过程新技术国家重点实验室, 江苏 连云港 222001;江苏康缘药业股份有限公司, 江苏 连云港 222001;中药制药过程新技术国家重点实验室, 江苏 连云港 222001;江苏康缘药业股份有限公司, 江苏 连云港 222001;中药制药过程新技术国家重点实验室, 江苏 连云港 222001 |
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| 基金项目： | 科学技术部国家重大新药创制项目(2013ZX09402203):现代中药创新集群与数字制药技术平台 |
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| 摘 要： | 目的应用信息熵理论优选热毒宁口服制剂中金银花与栀子的提取工艺。方法以绿原酸、栀子苷、木犀草苷提取率及浸膏得率为综合评价指标,选取提取时间、加水量及提取次数为影响因素,采用信息熵赋权法确定各指标的客观权重,实现对提取工艺的正交试验优选。结果最佳提取工艺为12倍量水提取3次,每次1 h。结论信息熵理论可用于热毒宁口服制剂中金银花与栀子提取工艺的优选。
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| 关 键 词： | 信息熵 热毒宁口服制剂 金银花 栀子 提取工艺 综合评价 |
| 收稿时间： | 9/3/2014 12:00:00 AM |
Application of information entropy theory in optimization of extraction technology for Lonicerae Flos and Gardeniae Fructus in Reduning Oral Preparation |
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| WANG Ren-jie,LI Miao,YAN Ming,YANG Su-de,WANG Zhen-zhong and XIAO Wei.Application of information entropy theory in optimization of extraction technology for Lonicerae Flos and Gardeniae Fructus in Reduning Oral Preparation[J].Chinese Traditional and Herbal Drugs,2015,46(5):683-687. |
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| Authors: | WANG Ren-jie LI Miao YAN Ming YANG Su-de WANG Zhen-zhong and XIAO Wei |
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| Institution: | Jiangsu Kanion Parmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China;Jiangsu Kanion Parmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China;Jiangsu Kanion Parmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China;Jiangsu Kanion Parmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China;Jiangsu Kanion Parmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China;Jiangsu Kanion Parmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China |
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| Abstract: | Objective To optimize the extraction technology for Lonicerae Flos and Gardeniae Fructus in Reduning Oral Preparation by information entropy theory. Methods With the contents of chlorogenic acid, gardenoside, luteoloside, and the yield of extract as comprehensive evaluation indexes, the extraction time, dosage of water, and extraction times were selected as factors, the weight of them was determined by information entropy theory, and the extraction technology was optimized by orthogonal test. Results Optimum extraction technology was: Reflux extraction for 3 times with 12 folds water, 1 h each time. Conclusion The information entropy theory could be used in optimizing the extraction technology for Reduning Oral Preparation. |
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| Keywords: | information entropy Reduning Oral Preparation Lonicerae Flos Gardeniae Fructus extraction technology comprehensive evaluation |
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