| 基质金属蛋白酶在角膜疾病中的作用 |
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| 引用本文： | 黎黎,秦莉,裴澄.基质金属蛋白酶在角膜疾病中的作用[J].国际眼科杂志,2006,6(1):169-172. |
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| 作者姓名： | 黎黎 秦莉 裴澄 |
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| 作者单位： | 710061,中国陕西省西安市,西安交通大学医学院第一医院眼科 |
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| 摘 要： | MMP作为降解细胞外基质的酶家族。参与许多生理及病理过程。同样其在角膜表达水平的改变与许多角膜疾病密切相关。随着对其研究的不断深入,使得从一个新的角度来预防和治疗角膜疾病成为可能。所以十分有必要了解MMPs的结构、功能、生物合成的调节及其在角膜疾病中的作用。
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| 关 键 词： | 基质金属蛋白酶 细胞外基质 角膜炎 角膜移植 角膜疾病 |
| 收稿时间： | 10 13 2005 12:00AM |
| 修稿时间： | 02 9 2006 12:00AM |
Effect of matrix metalloproteinases on corneal disease |
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| Li Li,Li Qin,Cheng Pei.Effect of matrix metalloproteinases on corneal disease[J].International Journal of Ophthalmology,2006,6(1):169-172. |
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| Authors: | Li Li Li Qin Cheng Pei |
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| Abstract: | Matrix metalloproteinases (MMPs) are a family of enzymes that play a vital role in degradating extracellular matrix (ECM). MMPs play a role in the basic cell biology underlying many physiological processes, and their roles in pathology can represent a loss of regulatory mechanisms leading to increased tissue destruction or deposition. Similar reflections also happen on cornea. This review focuses on the structure, function, regulation of MMPs and their role in the development of various corneal disorders. |
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| Keywords: | MMPs extracellular matrix (ECM) keratitis corneal transplantation corneal diseases |
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