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| 调督安神胶囊对PTX致痫大鼠海马神经元NMDAR1的影响 | |
| 引用本文： | 杨雁,白芬兰,裴林,刘树刚. 调督安神胶囊对PTX致痫大鼠海马神经元NMDAR1的影响[J]. 白求恩军医学院学报, 2008, 6(4): 201-203 |
| 作者姓名： | 杨雁 白芬兰 裴林 刘树刚 |
| 作者单位： | 1. 解放军第260医院,石家庄,050041 2. 白求恩军医学院,石家庄,050081 3. 河北省中医研究院,石家庄,050031 |
| 摘 要： | 目的探讨调督安神胶囊对PTX致痫大鼠海马N-甲基D-天冬氨酸受体亚单位NR1（NMDAR1）的影响。方法建立PTX癫痫大鼠模型，再随机分为模型对照组、中药低剂量组、中药高剂量组、西药组。分别给予双蒸水和调督安神胶囊、西药灌胃。然后进行NMDARl免疫组织化学染色和免疫阳性细胞记数。结果FIX致痫大鼠海马NMDAR1表达显著增强，而经过中药治疗后的癫痫大鼠海马NMDAR1阳性细胞数明显减少，接近于正常组。结论调督安神胶囊可以抑制海马组织中NMDAR1的过度表达，这可能是其改善癫痫大鼠学习和记忆障碍的机制之一。 |
| 关 键 词： | 癫痫 调督安神胶囊 N-甲基D-天冬氨酸受体亚单位NR1(NMDAR1) |
Effects of Tiaodu Anshen Capsule on the NMDAR1 in Hippocampus Neuron in Picrotoxin(PTX)-induced Epilepsy Rats |
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| YANG Yan,BAI Fenlan,PEI Lin,et al.. Effects of Tiaodu Anshen Capsule on the NMDAR1 in Hippocampus Neuron in Picrotoxin(PTX)-induced Epilepsy Rats[J]. Journal of Bethune Military Medical College, 2008, 6(4): 201-203 | |
| Authors: | YANG Yan BAI Fenlan PEI Lin et al. |
| Affiliation: | YANG Yan,BAI Fenlan,PEI Lin,et al.Section of TCM Physiotherapy,the 260 th Hospital of PLA,Shijiazhuang 050041,China |
| Abstract: | Objective To observe the effects of Tiaodu Anshen capsule on the NMDAR1 in hippocampus neuron in picrotoxin(PTX)-induced epilepsy rats.Methods The PTX-induced epilepsy rats were established,and then randomly divided into 4 groups:model control group,Chinese medicine low dosage group,high dosage group and western medicine group.The rats were treated with intragastric administration: Double distilled water,Tiaodu Anshen capsule and western medicine.The expressions of NMDAR1 in hippocampus neuron were evaluate... |
| Keywords: | Epilepsy Tiaodu Anshen capsule NMDAR1 |
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