The Influence of Urea on Percutaneous Absorption |
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| Authors: | Beastall Janet Guy Richard H. Hadgraft Jonathan Wilding Ian |
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| Affiliation: | (1) Department of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, U.K;(2) Departments of Pharmacy and Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, California, 94143;(3) The Welsh School of Pharmacy, UWIST, P.O. Box 13, Cardiff, CF1 3XF, U.K |
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| Abstract: | The release characteristics of aqueous and oily creams (BP) containing urea up to concentrations of 10% have been studied. The results show that the urea has little influence on the ability of the formulation to release its active ingredient, in this case, hexyl nicotinate. The preparations were then assessed in an in vivo experiment by measuring the time of onset of erythema induced by the hexyl nicotinate. The urea influenced the time of onset of erythema, and a mechanism for its action is proposed. |
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| Keywords: | penetration enhancers percutaneous absorption urea hexyl nicotinate |
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