| 阿霉素对去甲斑蝥素在大鼠体内药动学的影响 |
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| 引用本文： | 魏科达,徐幸民,徐虹,赵绪元,刘建宇.阿霉素对去甲斑蝥素在大鼠体内药动学的影响[J].中南药学,2009,7(7):502-506. |
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| 作者姓名： | 魏科达 徐幸民 徐虹 赵绪元 刘建宇 |
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| 作者单位： | 中南大学湘雅二医院药剂科,长沙,410011 |
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| 摘 要： | 目的研究大鼠静脉给予阿霉素（ADM）对去甲斑蝥素（NCTD）体内药物动力学的影响。方法用HPLC-MS方法测定ADM和NCTD合并给药与NCTD单独给药大鼠血浆中的NCTD浓度,比较两者的药动学参数。结果ADM和NCTD合并给药组与NCTD单独给药组相比在分布速度常数（α）、分布相半衰期（t1/2α）、中央室向周边室的转运速度常数（k12）3个药动学参数有统计学差异（P〈0.05）,其余药动学参数之间无显著差异（P〉0.05）。结论NCTD与ADM合用时,ADM不会显著影响NCTD在大鼠体内的药动学过程,两药合用增效的原因主要在于药效学上的协同作用。
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| 关 键 词： | 去甲斑蝥素 阿霉素 药物动力学 药物相互作用 |
Effect of adriamycin on pharmacokinetics of norcantharidin in rats |
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| WEI Ke-da,XU Xing-min,XU Hong,ZHAO Xu-yuan,LIU Jian-yu.Effect of adriamycin on pharmacokinetics of norcantharidin in rats[J].Central South Pharmacy,2009,7(7):502-506. |
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| Authors: | WEI Ke-da XU Xing-min XU Hong ZHAO Xu-yuan LIU Jian-yu |
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| Institution: | (Department of Pharmacy, Second Xiangya Hospital, Central South University, Changsha 410011) |
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| Abstract: | Objective To determine the effect of adriamycin on the pharmacokinetics of norcantharidin in rats.Methods Rats were divided into 2 groups:One group was treated with norcantharidin and the other with norcantharidin and adriamycin. Norcantharidin concentration in the two groups was detected by HPLC-MS. The pharmacokinetic parameters were statistically compared. Results The 3 pharmacokinetic parameters(α,t1/2(α) and k12)showed significant difference between the two groups (P>0.05).Conclusion Adriamycin has no significant effect on the pharmacokinetics of norcantharidin in rats.Enhanced efficiency of the two drugs in combination is mainly due to the synergism of pharmacodynamics. |
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| Keywords: | norcantharidin adriamycin pharmacokinetics drug interaction |
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