| 白细胞介素-22对细胞信号转导通路的影响 |
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| 引用本文： | 李炫昊,杜林栋. 白细胞介素-22对细胞信号转导通路的影响[J]. 国际外科学杂志, 2009, 36(12). DOI: 10.3760/cma.j.issn.1673-4203.2009.12.022 |
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| 作者姓名： | 李炫昊 杜林栋 |
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| 作者单位： | 首都医科大学附属北京友谊医院泌尿外科,北京,100050;首都医科大学附属北京友谊医院泌尿外科,北京,100050 |
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| 摘 要： | 白细胞介素-22(IL-22)是2000年发现的一种新型细胞因子,主要由活化的T1细胞和NK细胞分泌生成.其受体在人体皮肤、泌尿系统、消化系统及呼吸系统组织中均有较高的表达.研究发现IL-22不仅具有抗微生物感染、诱导急性炎性介质反应、防御及修复损伤、增强天然免疫等作用,最重要的它还能调节肿瘤细胞的增生、分化及凋亡过程,这为我们研究某些肿瘤的靶向治疗提供了新的启示.
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| 关 键 词： | 白细胞介素-22 信号转导 细胞增生 细胞凋亡 |
Effect of interleukin-22 on cell signaling pathways |
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| LI Xuan-Hao,DU Lin-Dong. Effect of interleukin-22 on cell signaling pathways[J]. International Journal of Surgery, 2009, 36(12). DOI: 10.3760/cma.j.issn.1673-4203.2009.12.022 |
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| Authors: | LI Xuan-Hao DU Lin-Dong |
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| Abstract: | Interleukin-22 (IL-22) is a new kind of eytokine discovered in 2000. The major sources of IL-22 are activated T1 -cells and NK-cells. Tissue cells at outer body barriers, i.e. of the skin, kidney, the di-gestive and respiratory systems all highly express IL-22R or respond to IL-22. IL-22 functions by promoting the anti-microbial defense, inducing phase reactants, protecting against damage and enhancing natural immu-nity. Furthermore, IL-22 mediates the proliferation, differentiation and apoptesis in cancer cells, that gives us a new idea about tumor therapy. |
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| Keywords: | interleukin-22 signaling pathways cell proliferation cell apoptosis |
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