| 1,25（OH）2D3和维甲酸对巨核白血病细胞的增殖抑制作用 |
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| 引用本文： | 程涛,万景华.1,25（OH）2D3和维甲酸对巨核白血病细胞的增殖抑制作用[J].第二军医大学学报,1991,12(1):24-27. |
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| 作者姓名： | 程涛 万景华 |
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| 作者单位： | 长海医院血液科，长海医院血液科，中国医学科学院血液学研究所，中国医学科学院血液学研究所 200433，200433，天津 300020，天津 300020 |
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| 摘 要： |
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| 关 键 词： | 维生素D3 维甲酸 白血病 增殖抑制 |
Inhibition of Proliferation of Megakaryoblastic Leukemic Cells by 1,25-Dihydroxyvitamin D_3 and Retinoic Acid |
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| Cheng Tao,Yan Fang,Wan Jinghua,Yin Jianlin.Inhibition of Proliferation of Megakaryoblastic Leukemic Cells by 1,25-Dihydroxyvitamin D_3 and Retinoic Acid[J].Academic Journal of Second Military Medical University,1991,12(1):24-27. |
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| Authors: | Cheng Tao Yan Fang Wan Jinghua Yin Jianlin |
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| Abstract: | The effect of inhibition of proliferation of a novel human megakaryoblastic leukemia cell line (HIMeg) by two physiological factors, 1.25-dihydroxyvitamin D3 1,25(OH)2 D3] and 13-cis-retinoic acid (RA), was investigated. At the range of 10-9 - 10-6 mol/L, 1,25(OH)2 D3 and RA showed significant inhibition of proliferation of the megakaryoblastic leukemia cells,which was demonstrated by count of survival cells,incorporation of 3H]-TdR and 3H]-UR, and cloning efficiency. From above, it can further explain the m.echanism of differentiation-inducers and the effect of 1,25(OH)2D3 on myelofibrosis. It is possible for 1,25(OH)2D3 and RA to be used for a new -treatment. |
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| Keywords: | 1 25-dihydroxyvitamin D3 retinoic acid megakaryoblastic leukemia cells proliferation inhibition |
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