| 小剂量柔红霉素对HL—60细胞增殖分化的影响 |
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| 引用本文： | 程涛 严航. 小剂量柔红霉素对HL—60细胞增殖分化的影响[J]. 第二军医大学学报, 1991, 12(4): 346-348 |
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| 作者姓名： | 程涛 严航 |
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| 作者单位： | 长海医院血液科 200433(程涛)，长海医院血液科 200433(严舫) |
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| 摘 要： |
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| 关 键 词： | 柔红霉素 白血病 HL－60细胞 |
Effects of Low-dose Daunorubicin on Proliferation and Differentiation of HL-60 cells |
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| Cheng Tao,Yan Fang. Effects of Low-dose Daunorubicin on Proliferation and Differentiation of HL-60 cells[J]. Former Academic Journal of Second Military Medical University, 1991, 12(4): 346-348 |
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| Authors: | Cheng Tao Yan Fang |
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| Abstract: | In order to probe into the mechanism of low-dose chemotherapeutic agents in the treatment of leukemia, we studied the effects of low concentrations (l-40ng/ml) of daunorubicin (DNR) on proliferation and differentiation of human promyelocytic leukemia cell line (HL-60). 1 ng/ml DNR could inhibit the proliferation of the cells, but no induction of differentiation was found. DNR at more than 5 ng/ml had both cytotoxicity and induction of differentiation. Through the count of survival cells, [3H]TdR and [3H]UR incorporation, cloning efficiency, cell morphology and NBT reduction test, it is concluded that low-dose DNR could have inhibitory and cytotoxic effects on the cells, and its inducing differentiation was not important. |
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| Keywords: | daunorubicin low-dose chemotherapy leukemia HL-60 cells proliferation differentiation |
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