血清胱抑素C、血脂及高敏C反应蛋白与糖尿病视网膜病变的相关性研究

目的 探讨2型糖尿病病人血清胱抑素C(Cys-C)、血脂水平以及高敏C反应蛋白(hs-CRP)水平及病程与2型糖尿病视网膜病变(DR)的相关性。方法收集本科室住院的糖尿病病人90例作为研究对象,根据DR病变程度分组,比较不同组别间病人Cys-C、血脂及hs-CRP水平。结果90例糖尿病,DR1期48例,占53.33%,DR2期14例,占15.56%,DR3期10例,占11.11%,DR4期6例,占6.67%,DR5期12例,占13.33%。随着分期的递增,其病程、血糖、糖化血红蛋白、血脂、hs-CRP、Cys-C以及24 h尿蛋白定量(24 h-UAE)水平依次升高,HDL-C水平呈依次降低；Spearman''s相关性分析显示,Cys-C,hs-CRP及病程与DR发生相关,是诱发DR的独立危险因素。结论Cys-C,Hs-CRP及病程是DR发病的独立危险因素,对于确诊为糖尿病的病人,应早期行眼底检查,及早发现视网膜病变,并控制血糖及血脂水平,以延缓DR的病情,改善临床结局。

Study on the relationship between serum cystatin C,blood lipid andhigh sensitive C reactive protein and diabetic retinopathy

Objective To investigate the relation between serum cystatin C (Cys),blood lipid,high-sensitivity C-reactive protein (hs-CRP) levels and course of disease in diabetic retinopathy (DR) correlation.Methods90 cases of diabetes mellitus patients were collected as the research object,and grouped according to the severity of DR,comparing the levels of Cys-C,blood lipid and hs-CRP of different groups.ResultsAmong 90 cases of diabetes,there were 48 cases of DR1(53.33%),14 cases of DR2(15.56%),10 cases of DR3(11.11%),6 cases of DR4(6.67%),12 cases of DR5(13.33%).Along with the up grade and prolong of course of disease,blood glucose,HbA1c,blood lipids,hs-CRP and Cys-C and 24 h- UAE levels were more than 1 phase and increased by grade of DR but not HDL-C level.By a Spearman''s regression analysis,Cys-C,hs-CRP and the course of disease were associated with DR and were independent risk factors for DR.ConclusionCys-C,hs-CRP and the course of disease are independent risk factors for the onset of DR,so the fundus examination and detection retinopathy should be actualized early for the diabetic patients,and the levels of blood glucose and blood lipid should be controlled,which were useful to delay DR condition and improve clinical outcomes.