| HIE新生儿血清NSE、Cor、ADM、钙、镁及血小板测定的临床意义 |
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| 引用本文： | 吕卫华,黄卫良.HIE新生儿血清NSE、Cor、ADM、钙、镁及血小板测定的临床意义[J].放射免疫学杂志,2009,22(5):444-446. |
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| 作者姓名： | 吕卫华 黄卫良 |
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| 作者单位： | 扬州大学第五临床医学院常熟二院儿科,215500 |
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| 摘 要： | 目的：探讨HIE患儿血清NSE、Cor及ADM测定的临床意义。方法：NSE、ADM均采用放射免疫分析,Cor测定则应用化学发光法;用邻甲酚酞络合酮法测定血清总钙,络合指示剂法测定血清镁;血小板计数应用Sysmex2100全自动血细胞分析仪测定。结果：轻度HIE组NSE及ADM两项指标与对照组比较差异无显著性（P〉0.05）;Cor水平则轻度组较对照组显著升高（P〈0.05）。中度HIE组NSE和Cor两项指标与对照组比较升高均极显著（P均〈0.01）;ADM水平较对照组升高亦具显著性（P〈0.05）。重度组两项指标较对照组升高均极显著（P均〈0.01）。血清总钙、镁及血小板两项指标的测定数据则均降低非常显著,与对照组相比（P均〈0.01）,差异有明显统计学意义,轻、中、重三组间三项血常规参数降低也较明显;三组间两两比较（P均〈0.05）,差异有统计学意义。结论：六项指标均参与了患儿HIE的发病过程,其测定对于了解患儿脑损伤程度有帮助。
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| 关 键 词： | 缺氧缺血性脑病 神经元特异性烯醇化酶 皮质醇 肾上腺髓质素 |
Clinical Significance of Changes of Serum NSE,Cortisol,ADM,Calcium,Magnesium Levels and Platalet Count in Neonates with Hypoxic-Ischemic Encephalopathy(HIE) |
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| Lu Weihua,Huang Weiliang.Clinical Significance of Changes of Serum NSE,Cortisol,ADM,Calcium,Magnesium Levels and Platalet Count in Neonates with Hypoxic-Ischemic Encephalopathy(HIE)[J].Journal of Radioimmanology,2009,22(5):444-446. |
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| Authors: | Lu Weihua Huang Weiliang |
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| Institution: | Lu Weihua,Huang WeiliangDepartment of Pediatrics,Changshu Municipal Second Hospital,Fifth Affiliated Clinical Medical College of Yangzhou University,Changshu(215500),China |
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| Abstract: | Objective To study the clinical significance of changes of serum NSE,cortisol,ADM,Ca++,Mg++ levels and platalet count in neonates with HIE.Methods Serum NSE,ADM(with RIA),cortisol(with CLIA),Ca++ and Mg++(with biochemistry) levels and platalet count were determined in 52 neonates with HIE(mild,n=26,moderate,n=16,advanced,n=10) and 30 controls.Results In the neonates with mild HIE,the serum NSE and ADM levels were not significantly different from those in controls(P>0.05) but cortisol levels were significant... |
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| Keywords: | hypoxic-ischemic encephalopathy neuron-specific enolase cortisol adrenomedullin |
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