人参注射液对肺源性心脏病急性发作期患者血浆一氧化氮、内皮素及血液流变性的影响

目的:观察人参注射液治疗肺源性心脏病(肺心病)急性发作期的疗效及其对血浆内皮素(ET 1)、一氧化氮(NO)及血液流变性的影响。方法:将70 例肺心病患者随机分为治疗组和对照组(各35 例)。对照组单以西药治疗;治疗组在常规西药治疗的基础上使用人参注射液,2 组疗程均为2 周。治疗前后作血浆ET 1、NO 及血液流变性的检测。结果:治疗组总有效率为88.6% ,显著优于对照组(68.6% ),P< 0.05;平均疗程治疗组显著低于对照组,P< 0.01;经治疗2 周后,治疗组ET 1 显著下降,NO、NO/ET 1 显著升高;血液流变性明显改善,均显著优于对照组,P< 0.05 和P< 0.01。结论:人参注射液治疗肺心病急性发作期不仅可提高临床疗效、缩短疗程,而且对干预ET 1、NO 的生成、释放及其活性,维持其动态平衡,改善血液流变性可能具有一定的作用

Influences of ginsen injection on plasma nitric oxide,endothelin-1 and blood rheology in patients with acutely seizure phase of cor pulmonale

Objective:To observe the curative effects and influences of ginsen injection on treating acutely seizure phase of cor pulmonale and on nitric oxide (NO),endothelin1 (ET1),and blood rheology.Methods:70 patients were randomly divided into treated group ( n =35) and control group ( n =35).The control group was treated with conventional therapy of western medicine (WM) alone while treated group based on conventional therapy of WM treated with ginsen injection.The therapeutic course was two weeks for both two groups.Before and after therapy the parameters of plasma ET1,NO,and blood rheology were detected. Results: In treated group the total effective rate (88 6%) was significantly superior to that (68 6%) in control gorup ( P <0 05).The therapeutic course on average in treated group was significantly lower than that in control group ( P <0 01).After twoweek therapy in treated group the ET1 was markedly decreased,the NO and NO/ET1 were markedly increased,the parameters of blood rheology were markedly improved,and all of them were significantly superior to those in control group ( P <0 05 or P <0 01).Conclusions:Ginsen injection in treating acutely seizure phase of cor pulmonale is able not only to heighten the clinically curative effects and to shorten the therapeutic course but also possibly to produce certain influences on the synthesis,release,and activity of ET and NO,on keeping the dynamic balance,and on improving the blood rheology.