参麦注射液对血液透析患者微炎症状态及左心室肥厚的影响

目的：研究参麦注射液对维持性血液透析（maintenance hemodialysis,MHD）患者微炎症状态及左心室肥厚（left ventricular hypertrophy,LVH）的影响。方法：MHD患者40例,随机分为参麦组和对照组,每组20例,治疗3个月,观察治疗前后血hs-CRP、IL-6、IL-1β水平,测定心超指标。结果：治疗后,参麦组的hs-CRP、IL-6、IL-1β水平明显降低（P〈0.05）,与对照组比较,hs-CRP、IL-6的降低差异有统计学意义（P〈0.05）;治疗后,参麦组LVM、LVMI、IVST降低,与治疗前相比差异有统计学意义（P〈0.01）;与对照组相比LVM、LVMI、IVST的降低差异均有统计学意义（P〈0.01和P〈0.05）。结论：参麦注射液可以改善MHD患者微炎症状态,逆转LVH。

Effect of Shenmai Injection on Status of Micro-Inflammation and Left Ventricular Hypertrophy in Hemodialysis Patients

Objective：To investigate the effect of Shenmai injection on the status of the micro-inflammation and left ventricular hypertrophy（LVH） in hemodialysis（HD） patients.Methods：Forty cases of hemodialysis patients were randomly allocated into two groups：the Shenmai group and the control group,with 20 cases in each group.The period of the treatment was three months.High sensitive C-reactive protein（hs-CRP）,interleukin-6（IL-6） and interleukin-1β（IL-1β） measurements and echocardiographic studies were performed in all patients before and after treatment.Results：After 3 months＇ treatment,the levels of hs-CRP、IL-6、IL-1β in Shenmai group were much lower than those before treatment（P〈0.05）;and the levels of hs-CRP、IL-6 in Shenmai group were much lower than those of control group（P〈0.05）.After 3 months＇ treatment,the levels of LVM,LVMI,IVST in Shenmai group were lower significantly than those before treatment（P〈0.01）;and the levels of LVM,LVMI and IVST in Shenmai group were lower than those of control group（P〈0.01 and P〈0.05）.Conclusion：Shenmai injection could effectively relieve the micro-inflammation reaction and LVH in hemodialysis patients.