女性海洛因依赖者子宫、卵巢变化的B超检查及探讨

阿片类药物可以使人体许多系统受累，海洛因对内分泌器的影响已经有多方面的报道。在戒毒工作中，女性吸毒者月经紊乱、闭经、流产很常见，除内分沁的改变外，子宫、卵巢有否变化引起我们的注意。为此，我们从３１８例女性吸毒者中，选择海洛因依赖者１０５例进行Ｂ超观察...

EFFICIENT ACTIVATION OF ANTITUMOR IMMUNITY BY IL 6 GENE MODIFIED LEUKEMIA VACCINE IN COMBINATION WITH LOW DOSE CYCLOPHOSPHAMIDE AND LOW DOSE IL 2

Objective: To investigate the antitumor effect of the IL 6 gene modified erythroleukemia cells combined with low dose cyclophosphamide (Cy) and low dose IL 2 Methods: Mice inoculated with FBL 3 IL 6 in combination with low dose IL 2 and low dose cyclophosphamide (Cy) Results: Mice received combined therapy of FBL 3 IL 6, IL 2 and Cy developed tumors most slowly and survived much longer when compared with mice in control groups, with 5 out of 8 leukemia bearing mice being tumor free 100 days after the combined treatment To further explain the mechanism of the antitumor effects by the combined therapy It was found that combined therapy with low dose Cy, low dose IL 2 and FBL 3 IL 6 achieved maximal cytotoxic effects of nature killer cells and specific cytotoxic T lymphocytes, increased production IL 2, TNF and GM CSF from spleen lymphocytes in tumor bearing mice Vaccination with the FBL3 IL 6 also enhanced the cytotoxic activity of the peritoneal macrophages The results demonstrated that administration of low dose Cy and low dose IL 2 in combination with IL 6 gene modified leukemia vaccine could elicit potent anti leukemia effects, and the mechanisms involved in the antitumor process may include the induction of specific and nonspecific antitumor immunity, reversal of T suppressor cells that mediated local immuno suppression in tumor bearing mice Conclusion: The combined therapy with cytokine gene modified tumor vaccine, low dose of Cy and IL 2 might be a promising approach for the treatment of leukemia