2型糖尿病患者血尿酸浓度与体脂情况的相关性分析

目的探讨2型糖尿病患者不同体脂情况与血尿酸浓度的相关性及其可能的影响因素。方法回顾分析532例住院2型糖尿病患者的体脂分布、血尿酸、血糖及肾功能等指标，对其血尿酸浓度与体脂分布进行单因素和多因素相关分析。结果在2型糖尿病患者中血尿酸浓度与体脂分布密切相关：（1）根据血尿酸浓度分组，高尿酸血症组的腰臀比、体质量指数、血尿素氮、血肌酐、甘油三酯明显高于正常尿酸组[分别为（0．94±0．07）与（0．91±0．07），（26．91±3．90）kg／m^2与（23．84±3．80）k/m^2，（8．66±5．94）mmol／L与（6．29±3．64）mmol／L，（93．9±67．6）p,molfL与（63．9±20．6）μmol／L，（2．65±1．92）mmol／L与（1．86±1．46）mmol／L，P均〈0．05]；而高密度脂蛋白胆固醇降低[分别为（1．09±O，32）mmol/L与（1．24±0．45）mmol／L，P〈0．05）。（2）多元回归分析结果显示血尿酸浓度与体质量指数、血肌酐、甘油三酯（b值分别为0．201、0．500、0．153，P〈0．05）呈正相关，与糖化血红蛋白、高密度脂蛋白胆固醇呈负相关（6值分别为-0．168、-0．121，P〈0．05）。结论在2型糖尿病患者中血尿酸浓度与体脂分布密切相关。对于2型糖尿病患者不仅要控制血糖，还应控制体质量，以降低糖尿病患者心脑血管疾病的发生率。

The relationship between serum uric acid level and body fat depots in type 2 diabetic patients

Objective To investigate the relationship between serum uric acid level and body fat depots as well as the possible influencing factors of the relationship in type 2 diabetic patients. Methods Five hundred and thirty two patients hospitalized for type 2 diabetes were recruited in this study. According to serum uric acid,the subjects were classified into normal uric acid group （ group NUA, n = 426 ） and high uric acid group （ group HUA, n = 106 ）. Anthropometry （ BMI, waist circumference, hip circumference and WHR） , serum uric acid level, blood glucose, renal function and lipid levels were compared between the two groups. Results Serum uric acid level was closely related to body fat distribution ： （ 1 ） in group HUA, WHR, BMI, BUN, SCr and TG were significantly higher than that of group NUA （ [ 0. 94 ± 0. 07 3 vs. [ 0. 91 ：e O. 07 ], [ 26. 91± 3.90 kg/m2 vs. [ 23.84 ± 3.80 ] kg/m2, E 8.66 ± 5.94 ] mmol/L vs. L 6. 29 ± 3.64 ] mmol/L, [ 93.9± 67.6 ] μmol/L vs. [ 63.9 ± 20. 6 ] μmol/L, [ 2. 65 ± 1.92 ] mmol/L vs. [ 1.86 ± 1.46 ] mmol/L, respectively; all P 〈 0.05 J ; while HDL-C was lower in Group HUA than in group NUA （ [ 1.09 ± O. 32 ] mmol/L vs. [ 1.24 ± 0. 45 ] mmol/L, P 〈 O. 05 ）. （2） Multiple regression analysis revealed that the serum uric acid levels were positively correlated with BMI, SCr, and TG （ b = 0. 201,0. 500,0. 153, respectively, P 〈 O. 05 ）, but negatively correlated with HbA1 c and HDL-C （ b = - 0. 168 and - O. 121, P 〈 0.05 ）. Conclusion In patients with type 2 diabetes, serum uric acid levels are closely related with the BMI and Glucose/lipid metabolism, which suggests that body weight control is as important as the uric acid lowering treatment in patients with type 2 diabetes to cut the risks of cardiac and vascular diseases.