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| 氢气对体外循环肺损伤的影响 | |
| 引用本文： | 胡啸玲,汤恢焕,周志刚. 氢气对体外循环肺损伤的影响[J]. 中国动脉硬化杂志, 2011, 19(2): 110-114 |
| 作者姓名： | 胡啸玲 汤恢焕 周志刚 |
| 作者单位： | 1. 中南大学附属湘雅医院普通外科,湖南省长沙市,410078;南华大学附属第一医院麻醉科,湖南省衡阳市,421001 2. 中南大学附属湘雅医院普通外科,湖南省长沙市,410078 3. 南华大学附属第一医院麻醉科,湖南省衡阳市,421001 |
| 摘 要： | 目的观察体外循环时吸入2%氢气对体外循环(CPB)肺损伤的影响。方法将Beagle犬随机分为两组:体外循环组(对照组),体外循环维持2 h,体外循环结束后继续观察2 h;氢气组,实验全程吸入氢气1 L/min。实验过程中在体外循环前(T0)、体外循环结束时(T1)、体外循环结束后15 min(T2)、60 min(T3)及120 min(T4)记录中心静脉压(CVP)、肺动脉压(PAP)及肺毛细血管楔压(PCWP),采动脉血行血气分析计算氧合指数(PaO2/FiO2)。采集血标本监测血浆肿瘤坏死因子(TNF-α)、白细胞介素6,白细胞介素8的变化。实验结束时监测支气管肺泡灌洗液(BALF)蛋白含量、白细胞计数,测定肺组织丙二醛(MDA)、超氧化物歧化酶(SOD)、髓过氧化物酶(MPO)及肺组织湿干重比(W/D),并对肺组织进行光镜及电镜观察。结果与对照组相比,氢气组肺动脉压(PAP)、外周血管阻力(PVR)及氧合指数PaO2/FiO2有明显改善,差异有统计学意义(P<0.05)。氢气能够显著降低炎症因子(TNF-α、IL-6和IL-8)释放,减轻组织氧化损伤(MDA、MPO及W/D低于对照组组,而SOD显著高... |
| 关 键 词： | 心肺转流 肺损伤 氢气 |
| 收稿时间： | 2010-11-25 |
Hydrogen Inhalation Alleviates Cardiopulmonary Bypass Induced Acute Lung Injury in Beagle Dogs |
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| HU Xiao-Ling,TANG Hui-Huan,and ZHOU Zhi-Gang. Hydrogen Inhalation Alleviates Cardiopulmonary Bypass Induced Acute Lung Injury in Beagle Dogs[J]. Chinese Journal of Arteriosclerosis, 2011, 19(2): 110-114 | |
| Authors: | HU Xiao-Ling TANG Hui-Huan and ZHOU Zhi-Gang |
| Affiliation: | HU Xiao-Ling1,2,TANG Hui-Huan1,and ZHOU Zhi-Gang2(1.Department of General Surgery,Xiangya Hospital of the Central South University,410011,2.Department of Anesthesiology,The First Affiliated Hospital of the University of South China,421001) |
| Abstract: | Aim To investigate the therapeutic effect of Hydrogen inhalation on cardioplumonary bypass(CPB) induced acute lung injury(ALI) in Beagle dogs. Methods CPB models were set up with living Beagle dogs.20 dogs were divided into hydrogen inhalation group(H2 group) and control group(C group) randomly.Pulmonary artery pressue(PAP),pulmonary capillary wedge pressure(PCWP) and pulmonary vascular resisitance(PVR) were recorded at the five defined time points,artery blood samples were obtained for blood gas analysis a... |
| Keywords: | Cardiopulmonary Bypss Lung Injury Hydrogen |
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