| 参松养心胶囊改善心力衰竭大鼠QT离散度及缝隙连接蛋白43的表达 |
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| 引用本文： | 杨军,周先令,褚春,彭葳锐,谭芳,丁赛良,谭小进.参松养心胶囊改善心力衰竭大鼠QT离散度及缝隙连接蛋白43的表达[J].中国动脉硬化杂志,2011,19(3):197-201. |
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| 作者姓名： | 杨军 周先令 褚春 彭葳锐 谭芳 丁赛良 谭小进 |
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| 作者单位： | 南华大学附属第一医院心内科,湖南省衡阳市,421001 |
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| 基金项目： | 中华医学会临床医学科研专项基金(09010280183) |
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| 摘 要： | 目的观察参松养心胶囊对压力超负荷所致心力衰竭大鼠的QT离散度及缝隙连接蛋白43表达的干预作用。方法采用腹主动脉缩窄法建立大鼠心力衰竭模型,经参松养心胶囊治疗8周。用皮下插入自制电极检测心室电生理变化,经HE染色观察其形态结构变化,Masson染色判断心肌纤维化沉积,免疫组织化学法观察缝隙连接蛋白43在左心室心肌组织的分布。结果心力衰竭大鼠QT离散度明显延长(37.20±9.94 ms,P<0.05),心肌细胞排列紊乱,心肌组织纤维沉积面积明显增加(101217.30±33970.02μm2,P<0.05),心肌组织缝隙连接蛋白43表达明显减少(55.93±11.61,P<0.05)。参松养心胶囊可缩短心力衰竭大鼠的QT离散度(25.50±8.21 ms),减少心肌组织纤维沉积面积(13580.64±8213.73μm2)并增加缝隙连接蛋白43的表达(69.09±16.59)。结论参松养心胶囊可以缩短心力衰竭大鼠的QT离散度,增加心肌组织缝隙连接蛋白43表达并减少纤维化面积。
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| 关 键 词： | 参松养心胶囊 心力衰竭 大鼠 QT离散度 缝隙连接蛋白43 |
| 收稿时间： | 2010/11/26 0:00:00 |
Effect of Shensongyangxin Capsule on QT Dispersion and Connexin43 Expression in Heart Failure Rats |
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| YANG Jun,ZHOU Xian-Ling,CHU Chun,PENG Wei-Rui,TAN Fang,DING Sai-Liang,and TAN Xiao-Jin.Effect of Shensongyangxin Capsule on QT Dispersion and Connexin43 Expression in Heart Failure Rats[J].Chinese Journal of Arteriosclerosis,2011,19(3):197-201. |
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| Authors: | YANG Jun ZHOU Xian-Ling CHU Chun PENG Wei-Rui TAN Fang DING Sai-Liang and TAN Xiao-Jin |
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| Institution: | YANG Jun,ZHOU Xian-Ling,CHU Chun,PENG Wei-Rui,TAN Fang,DING Sai-Liang,and TAN Xiao-Jin(Department of Cardiology,the First Affiliated Hospital,University of South China,Hengyang,Hunan 421001,China) |
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| Abstract: | Aim To investigate the effect of Shensongyangxin capsule on QT dispersion and connexin43 expression in heart failure rats. Methods Heart failure rats models were built by constricting abdominal aorta,and were lavaged with Shensongyangxin capsule for 8 weeks.Ventricular electrophysiology were measured by inserting home-made electrode into subcutaneous,left ventricular morphostructure,myocardial fibrosis,and connexin43 distribution were respectively observed by HE staining,Masson staining,immunohistochemical ... |
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| Keywords: | Shensongyangxin Capsule Heart Failure Rat QT Dispersion Connexin43 |
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